脑动脉硬化症患者脑血管血流动力学研究  

The Change of Cerebrovascular Hemodynamics of Cerebrovascular Atherogenesis

作　　者：杨剑波[1] 崔长琮[2] 武成斌[1] 

机构地区：[1]西安交通大学第一医院神经内科,陕西省西安市710061 [2]西安交通大学第一医院心内科,陕西省西安市710061

出　　处：《中国动脉硬化杂志》2010年第9期722-724,共3页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨脑动脉硬化症患者脑血管血流动力学的变化及导致脑梗死的机制。方法应用上海仁和医疗设备公司生产的脑循环动力学检测仪和以色列Link-9000型经颅多普勒诊断仪(TCD),对26例无明显神经系统体征、CT和MRI上无梗死灶的临床上诊断为脑动脉硬化症的患者进行了血流动力学研究。结果通过与脑梗死组及正常对照组对照研究,发现脑动脉硬化症患者双侧颈动脉供血量及血流速度与正常对照组相比差异无显著性(P>0.05),脑血管阻力及临界压力升高与正常对照组相比差异有显著性(P<0.05),脑动脉弹性及脑血流自动调节能力下降。TCD显示脑动脉硬化症患者大脑前动脉、大脑中动脉等主要脑动脉的血流速度大致在正常范围,而搏动指数较正常对照组有所增大(P<0.05)。脑梗死患者病灶侧大脑半球总供血量及血流速度明显下降,反映脑动脉硬化指标中R、DR、Cp较脑动脉硬化症患者严重。结论脑动脉硬化的存在并不直接影响一侧大脑半球主要脑血管的供血量,而脑循环阻力增高及自动调节功能减退可能是动脉硬化导致脑梗死血流动力学的重要机制。Aim and Methods The change of cerebrovascular hemodynamic index（CVDI）and Doppler expression of 26 patients with cerebrovascular atherogenesis using the surveying instrument of cerebrovascular hemodynamics were studied. Results ①In most of the patients two sides of total cerebral blood flow and the velocity didn＇t decrease,the cerebrovascular resistance,elasticity and cvitical pressure increased.The function of cerebrovascular regulation deteriorated.②The Trans-Link Doppler found： the blood flow and the velocity of anterior cerebrovascular artery,middle cerebrovascular artery were in normal range.Cerebral vascualr atherogenesis index especially the（Pulstility P1） increased.③The CVDI had remarkable changes in the lesion side of brain hemisphere,especially the total cerebral blood flow and the velocity decreased. Conclusion The cerebrovascular resistance and the function of cerebrovascular regulation are more serious than that of cerebrovascular atherogenesis.

关 键 词：脑动脉硬化症 脑循环动力学参数 脑梗死 

分 类 号：R741[医药卫生—神经病学与精神病学]