NF-κB在前列腺癌发生中的作用及可能机制  

Role and possible mechanism of NF-κB in tumorigenesis of prostate cancer

作　　者：韩慧[1] 许青[1] 

机构地区：[1]上海同济大学附属第十人民医院肿瘤科,上海200072

出　　处：《中国肿瘤生物治疗杂志》2010年第5期579-583,共5页Chinese Journal of Cancer Biotherapy

基　　金：国家自然科学基金资助项目(No.30872591)~~

摘　　要：前列腺炎是前列腺癌的危险因素之一,核转录因子-κB(nuclear factorκB,NF-κB)在前列腺炎诱发前列腺癌的过程中起重要作用。作为炎症环境特点之一的缺氧与参与免疫应答的Toll样受体,均可激活NF-κB;同时炎症细胞亦可通过NF-κB影响肿瘤的生物学行为;此外,NF-κB与其他前炎症因子间存在交互作用。NF-κB通过多途径调控肿瘤生长,包括促凋亡、抑增殖,介导肿瘤侵袭、转移和血管生成,同时可能诱导前列腺癌向雄激素非依赖性阶段演进。抗炎及针对NF-κB的靶向治疗为前列腺癌的治疗提供新思路,有待进一步深入研究。Prostatitis is a risk factor of prostate cancer.Nuclear factor-κB（NF-κB） plays an important role in the tumorigenesis of prostate cancer induced by prostatitis.Hypoxia,a marker of inflammation,and Toll like receptors both can activate NF-κB.Inflammatory cells can regulate the biological behavior of tumors through NF-κB.Moreover,NF-κB has a cross-talk with many pro-inflammatory factors.NF-κB regulates tumor growth through various ways,including apoptosis promotion and proliferation suppression,mediation of invasion,metastasis and angiogenesis of tumors;NF-κB also can induce progression of prostate cancer from the androgen-dependent to the androgen-independent stage.Anti-inflammation and NF-κB-targeting therapies cast new lights on prostate cancer treatment,which deserves further study.

关 键 词：核转录因子-κB(NF-κB) 前列腺肿瘤 前列腺炎 雄激素非依赖性 

分 类 号：R737.25[医药卫生—肿瘤] R730.2[医药卫生—临床医学]