脑胶质瘤表面通透性在术前分级中的价值及其与血管内皮生长因子表达的关系  

Surface Permeability of brain glioma using multi-slice CT perfusion imaging in preoperative grading and its relationship with the vascular endothelial growth factor expression of tumor

作　　者：史军丽[1] 张体江[1] 先正元[1] 范奇文[1] 彭岚[1] 刘华庆[2] 石荣书[1] 关晶[1] 骆科进[1] 

机构地区：[1]遵义医学院附属医院放射科,贵州563000 [2]遵义医学院附属医院病理科,贵州563000

出　　处：《放射学实践》2010年第11期1208-1211,共4页Radiologic Practice

基　　金：贵州省科学技术基金资助项目(黔科合J2007-2130)

摘　　要：目的：利用多MSCT灌注成像探讨脑胶质瘤表面通透性（PS）值在其术前分级中的价值及与血管内皮生长因子（VEGF）表达程度的相关性.方法：对37例CT平扫疑为脑胶质瘤患者行MSCT灌注成像扫描,观察肿瘤灌注PS图的特点,分析不同病理分级脑胶质瘤实质区的PS值的差异,术后对肿瘤组织行免疫组化检查,观察VEGF表达程度,并与肿瘤的分级及PS值进行对照分析.结果：37例中胶质瘤Ⅰ～Ⅱ级11例,Ⅲ级19例,Ⅳ级7例.不同级别组胶质瘤实质的PS均值分别为（3.38±1.62）、（14.83±3.10）及（38.03±9.02）ml/（min·100mg）,相应VEGF表达的平均光密度（ALD）值分别为0.108±0.038、0.197±0.042及0.256±0.050.胶质瘤的PS值及VEGF表达的ALD值均随脑胶质瘤病理级别的升高而升高,组间差异有极显著性意义（F=28.44,P〈0.01）.胶质瘤实质区最大PS值与VEGF的ALD值呈正相关（r=0.79,P〈0.05）.结论：CT灌注成像PS值可间接反映胶质瘤的血管生成情况,为脑胶质瘤术前分级提供重要的功能信息.Objective：To study the value of surface permeability （PS） of brain tumor using multi-slice CT （MSCT） perfusion imaging in the preoperative histological grading of brain glioma and correlated with vascular endothelial growth factor （VEGF） expression of the tumor. Methods： MSCT perfusion imaging was performed in 37 patients with suspected brain glioma on plain CT,the PS images were studied and PS value of different pathology grading of glioma were analyzed before surgery. The VEGF expression were measured using immuno histochemical technique after surgery and the tumor grading was correlated with PS value and VEGF expression. Results：Of the 37 patients,there were Grade Ⅰ - Ⅱ glioma （11 cases） ,grade Ⅲ （19 cases） and grade Ⅳ （7 cases）. The mean PS value and average luminance density （ALD） of VEGF expression were （3.38±1.62）ml/（min · 100mg） ,（14.83±3. 10）ml/（min · 100mg）,（38.03±9.02）ml/（min · 100mg） and （0. 108±0. 038） ,（0. 197±0. 042） ,（0. 256±0. 050） respectively,which increased in accordance with the grading of glioma with significant statistical difference （F=28.44,P〈0.01）. The highest PS value of solid part of glioma was positively correlated with the AL1） value of VEGF expression （r=0.79）. Conclusion：The PS value of cerebral glioma on CT perfusion imaging could indirectly reflect the angiogenesis of cerebral glioma and provided valuable functional information in the pre operative grading of brain glioma.

关 键 词：脑肿瘤 胶质瘤 灌注成像 表面通透性 血管内皮生长因子 

分 类 号：R739.4[医药卫生—肿瘤]