胆管癌耐药相关蛋白LRP和P170的表达及临床意义  

Expression of multidrug resistance-related proteins LRP/P170 in cholangiocarcinoma and its significance

作　　者：刘伟[1] 安杰[2] 侯会池[1] 

机构地区：[1]北京军区白求恩国际和平医院肝胆外科,河北石家庄050082 [2]北京军区白求恩国际和平医院病理科,河北石家庄050082

出　　处：《中国现代普通外科进展》2010年第9期676-678,共3页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:探讨胆管癌组织中肺耐药蛋白(LRP)和P糖蛋白(P170)的表达情况及其临床意义。方法:收集手术切除的21例胆管癌标本,采用免疫组织化学方法检测组织中LRP及P170的表达及其与临床病理因素的关系。结果:LRP和P170在胆管癌组织中的表达阳性率分别为61.9%和66.7%,显著高于对照组的12.5%和25.0%(P<0.05)。上述指标与性别、年龄、病理分期、分化程度、淋巴结转移均无关(P>0.05)。结论:LRP和P170在未经化疗的胆管癌组织中均有不同程度的高表达,胆管癌的原发性多药耐药可能与LRP和P170有关。Objective：Multidrug resistance is the main cause forthe patients with cholangiocarcinoma for not responding to chemotherapy.The expression of lung resistance protein（LRP）,glutathione P-glycoprotein（P170）were investigated in cholangiocarcinoma.Methods：Twenty one cases of cholangiocarcinoma were investigated and 8 cases of choledochitis served as the control group.LRP,P170 were measured by immuno-histochemistry method.Results：The positive rate of LRP,P170 in cholangiocarcinoma were 61.9% and 66.7% respectively,significantly higher than those of control group 12.5% and 25%（P〈0.05）.The expressions were not related to gender,age,staging,differentiation and lymph node metastasis （P〉0.05）.Conclusions：LRP and P170 were overexpressed in various degrees in cholangiocarcinoma without chemotherapy,which may be related to the primary multidrug resistance of the tumors.

关 键 词：胆管肿瘤 多药耐药相关蛋白质类 肺耐药蛋白 P糖蛋白 

分 类 号：R735.8[医药卫生—肿瘤]