GULP1基因多态性与精神分裂症及其认知功能的相关性研究  

The correlation of GULP1 gene polymorphism with the cognitive function in schizophrenia

作　　者：刘军[1] 虞洪 顾宝罗[1] 贺超奇[1] 

机构地区：[1]杭州市萧山区第一人民医院检验科,浙江省杭州311201 [2]浙江省萧山医院精神卫生中心

出　　处：《中国基层医药》2010年第21期2926-2928,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：基金项目：浙江省杭州市萧山区科技局项目（2008078）

摘　　要：目的探讨GULPl基因多态性与精神分裂症及认知功能的关系。方法采用聚合酶链反应限制性片段长度多态性（PCR—RFLP）的方法检测86例精神分裂症患者（观察组）和72名健康人（对照组）的GULPI基因SNPrs2004888多态性；采用韦氏记忆量表（WMS）和威斯康辛卡片分类测验（WCST）评估两组记忆功能和执行功能，并用PANSS量表评定患者的临床症状。观察两组GULPl基因多态性及认知功能的差异。结果两组GULPl基因SNPrs2004888多态性的基因型和等位基因频率差异有统计学意义（x2=35．71、32．21，均P〈0．05）；观察组各基因型组问韦氏记忆量表的理解记忆评分差异有统计学意义（P〈0．05）；G／G与T／T基因型患者比较，错误数、持续错误数和分类个数差异有统计学意义（P〈0．05）。结论GULPl基因SNPrs2004888多态性频度增高与精神分裂症有一定的关联，且与患者的认知功能相关。Objective To discuss the relationship between GULP1 gene polymorphism of Chinese Han population and schizophrenia, cognitive function. Methods Polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） method was used to detect 86 patients with schizophrenia and 72 normal controls GULP1 gene SNPrs2004888 polymorphism;Wechsler Memory Scale（WMS） and Wisconsin Card Sorting Test（WCST） assessment of two groups of memory and executive function, and assessed with the PANSS scale clinical symptoms. Results The differences of GULP1 gene SNP（rs2004888） polymorphism genotype and allele frequency was statistically significant （ x2 = 35.71,32. 21, all P 〈 0. 05 ）, Genotypes in patients with group comparison of cognitive function between groups showed the genotype groups Wechsler Memory Scale Logical Memory scores were significant （ P 〈 0.05 ） , G/G and T/T genotype compared with the Wisconsin Card Sorting Test in the number of errors, error numbers and classification numbers significant （P 〈 0. 05）. Conclusion GULP1 gene SNPrs2004888 polymorphism was associated with schizophrenia, and also related to cognitive function in schizophrenia.

关 键 词：精神分裂症 多态性 单核苷酸 认知 

分 类 号：R74[医药卫生—神经病学与精神病学]