急性白血病患者血浆VEGF、TF水平测定及其临床意义  

Clinical significance of plasma VEGF and TF concentration in acute leukemia

作　　者：李靖[1] 黄加忠[1] 徐秋节[1] 杨学艺[1] 王季茹[1] 

机构地区：[1]淮阴卫生高等职业技术学校,江苏淮安223300

出　　处：《现代生物医学进展》2010年第21期4104-4106,共3页Progress in Modern Biomedicine

摘　　要：目的:研究血清中血管内皮生长因子(VEGF)和组织因子(TF)的表达及其与急性白血病发生和发展的关系。方法:收集70例急性白血病患者(AL),其中初发未治者31例,完全缓解者14例,未缓解者7例,复发患者18例,另外选择20名健康体检者作为对照组,应用酶联免疫吸附试验(ELISA)法测定各组血清中VEGF及TF的含量,并进行统计学分析。结果:AL初发未治组、未缓解组、复发组患者血清VEGF和TF的含量均明显高于正常对照组和缓解组(P<0.01);而缓解组患者血清VEGF和TF的含量与正常对照组比较其差异无统计学意义(P>0.05);TF含量与VEGF含量在AL中呈显著正相关(r=0.675,P<0.01)。结论:VEGF和TF与AL的发生、发展密切相关,动态检测急性白血病患者的血清VEGF及TF水平对观察病情、预测复发、指导治疗均有十分重要的临床价值。Objective：To investigate the relationship between the concentration of plasma VEGF,TF and clinical condition in acute leukemia.Methods：The concentration of plasma VEGF and TF in 31 de novo,14 complete remitted（CR）,7 unremitted,18 relapsed patients with AL were measured by enzyme-linked immunosorbent assay（ELISA）,and compared with those of normal controls.Results：The concentration of plasma VEGF and TF in the acute leukemia group,unremitted group and relapsed group was significantly higher than those in control and remission group（P〈0.01）.There was no significant difference between the remission group and control group（P〉0.05）.There was linear correlation between the plasma TF and VEGF concentration（r=0.675,P〈0.01）.Conclusion：The con-centration of plasma VEGF and TF is significantly associated with clinical condition,which can be the indicators for learning clinical fea-tures and predicting prognosis of acute leukemia patients.

关 键 词：急性白血病 血管内皮细胞生长因子 组织因子 

分 类 号：R733.7[医药卫生—肿瘤]