哌甲酯对注意缺陷多动障碍患儿探究性眼球运动的影响  

Effect of Methylphenidate on Exploratory Eye Movement in Children with Attention Deficit Hyperactivity Disorder

作　　者：郭蕴岚[1] 郭蕴琦[2] 段敬利[3] 杨庆南[3] 陈根荣[4] 张文新[5] 姜文涛[3] 

机构地区：[1]新乡医学院第三附属医院药剂科,河南新乡453003 [2]新乡医学院第一附属医院药剂科,河南卫辉453100 [3]新乡医学院第二附属医院电生理室,河南新乡453002 [4]焦作煤业集团中央医院内科,河南焦作454000 [5]焦作煤业集团中央医院外科,河南焦作454000

出　　处：《实用儿科临床杂志》2010年第22期1748-1749,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的比较注意缺陷多动障碍(ADHD)儿童服用哌甲酯治疗前后其探究性眼球运动(EEM)的变化。方法收集ADHD患儿32例(病例组),男23例,女94例;年龄(10.25±2.08)岁,口服哌甲酯后进行EEM检测;30例健康儿童作为对照组;比较二组儿童眼球注视点数目(NEF)、反应性探究评分(RSS)的差异。应用SPSS 13.0软件进行统计学分析。结果 ADHD患儿服药后其NEF[(26.59±3.83)个]、RSS[(5.97±1.59)分]较服药前NEF[(23.77±5.29)个]、RSS[(5.03±1.80)分]增高,差异具有统计学意义(Pa<0.05),但服药后较健康对照组NEF[(28.40±2.58)个]、RSS[(7.83±1.91)分]降低,二者比较差异有统计学意义(P<0.05,0.01)。结论哌甲酯可能会改善ADHD儿童额叶-纹状体环路的注意性和抑制性执行功能。Objective To investigate the effect of methylphenidate in children with attention deficit hyperactivity disorder（ADHD） by detecting exploratory eye movements（EEM）.Methods Thirty-two children with ADHD（treatment group） were treated for oral use methylphenidate,30 healthy children were selected as healthy control gyoup,EEM of children in both groups were detected.The differences of the numbers of eye fixations（NEF）and responsive search score（RSS） between the 2 groups were compared using SPSS 13.0 software.Results The NEF was（26.59±3.83）and RSS score was（5.97±1.59）in treatment group after treatment,which were significantly higher than those before treatment（23.77±5.29,5.03±1.80）（Pa0.05） and significantly lower than those in healthy control group（28.40±2.58,7.83±1.91）（P0.05,0.01）.Conclusion Methylphenidate may improve the attention and inhibition executive functions of loop of forehead-striatum in children with ADHD.

关 键 词：注意缺陷多动障碍 哌甲酯 探究性眼动 额叶-纹状体环路 执行功能 

分 类 号：R749.94[医药卫生—神经病学与精神病学]