阻断花生四烯酸的代谢途径对胰腺癌细胞增殖的影响  

Effect of inhibiting the metabolization in arachidonic acid on proliferation of pancreatic cancer cell

作　　者：朱陈[1] 周国雄[2] 孙源源[1] 张振中[1] 金燕[1] 

机构地区：[1]江苏省南通市第三人民医院 [2]南通大学附属医院

出　　处：《齐齐哈尔医学院学报》2010年第16期2527-2528,共2页Journal of Qiqihar Medical University

摘　　要：目的探讨阻断花生四烯酸(arachidonic acid,AA)代谢途径抑制胰腺癌细胞增殖的情况。方法将胰腺癌细胞SW1990分为对照组,MK886干预组、Celecoxib干预组,CCK-8法检测胰腺癌细胞增殖情况。结果 MK886、Celecoxib均可抑制胰腺癌细胞的增殖。结论花生四烯酸与胰腺癌发生有密切关系,通过阻断花生四烯酸代谢可达到抑制胰腺癌细胞增殖的目的。Objective To study the effect of inhibiting the metabolization in arachidonic acid on proliferation in pancreatic cancer cell.Methods Cultured pancreatic cancer cell SW1990were effected by different concentrations of MK886,celecoxib.The effect of growth suppression on pancreatic cancer cell was SW1990.Results The proliferation of SW1990treated by MK886or celecoxib alone was depressed.Conclusions Both ways of arachidonic acid＇s metabolism have affinity on pancreatic cancer.

关 键 词：胰腺癌细胞 花生四烯酸 MK886 CELECOXIB 

分 类 号：R282.71[医药卫生—中药学]