microRNA在人类癌症治疗中的应用前景  

Application perspectives of microRNA-based human cancer therapy

作　　者：程娜[1] 王凯慧[1] 孙树汉[1] 

机构地区：[1]第二军医大学医学遗传学教研室,上海200433

出　　处：《分子诊断与治疗杂志》2010年第6期413-416,共4页Journal of Molecular Diagnostics and Therapy

基　　金：国家高技术研究发展计划(863计划)(2006AA02A238);全军"十一五"科技攻关项目(06G067)

摘　　要：microRNAs(miRNAs)是一类长度在18～25个核苷酸左右的内源性非编码小分子RNA,通过与靶mRNAs3'端非翻译区结合发挥其调节功能。miRNAs在人类肿瘤的发生和发展中扮演重要角色,发挥着癌基因或抑癌基因的作用,有望成为癌症治疗的作用靶点。本综述主要介绍了以miRNAs为基础的治疗方法在人类癌症治疗中的应用前景。microRNAs （miRNAs） are a group of 18-25 nucleotide long, noncoding, endogenous small RNA molecules which can exert its function by binding to the 3＇-untranslated region of a subset of mRNAs. miRNAs play important roles in the progression of human cancer, acting as oncogenic miRNAs or tumor suppressor miRNAs, and may turn out to be potential targets for cancer therapy. This review will highlight the perspectives of microRNA-based human cancer therapy.

关 键 词：微小RNAS 癌症 治疗 

分 类 号：R730.5[医药卫生—肿瘤]