复方樟柳碱对大鼠视网膜缺血再灌注损伤的保护作用  

Protection effect of compound anisodine in rats with retinal ischemia-reperfusion injury

作　　者：赵易[1] 陈丽娟[1] 

机构地区：[1]中国上海市普陀区人民医院眼科,200061

出　　处：《国际眼科杂志》2010年第12期2268-2270,共3页International Eye Science

摘　　要：目的:探讨复方樟柳碱对大鼠视网膜缺血再灌注损伤的治疗作用。方法:将成年雌性Wistar大鼠随机分成正常对照组,造模组和复方樟柳碱组,每组10只。采用前房灌注升高眼压制作急性视网膜缺血模型。观察1,3,7d视网膜电图a波b波的恢复情况。每组随机取2只大鼠造模眼球光镜、电镜下观察视网膜形态结构的变化,以及神经节细胞线粒体的变化。结果:复方樟柳碱组较造模组神经节细胞线粒体肿胀程度轻,b波明显恢复,同造模组与正常组间b波的恢复比较差异有显著统计学意义(P<0.01)。结论:复方樟柳碱可减轻大鼠视网膜缺血再灌注损伤,有神经细胞保护作用。AIM： To investigate the therapeutic effect of compound anisodine in rats with retinal ischemia-reperfusion injury. METHODS： Totally 30 adult female rats were divided into three groups at random. Group 1（n=10）：normal control;group 2（n=10）：high intraocular pressure （IOP）induced ocular ischemia model; group 3（n=10）：compound anisodine treatment. At the 1 day, 3,7 days the recovery condition of a-wave and b-wave by electroretinogram were observed in each group respectively. The morphology of retinal were observed by light microscope（n=2） in each group randomly. Retinal morphology and ganglion cells mitochondrion were evaluated by electron microscope. RESULTS： In our research, the recovery of b-wave in group 3 were better than that in group 1 and 2, and showed significant difference（P〈0.01） .In addition, group 3 ganglion cells mitochondrion swelling were lighter than that in group 2. CONCLUSION： Compound anisodine can ameliorate the retinal ischemia-reperfusion injury in rats. 

关 键 词：缺血再灌注 复方樟柳碱 

分 类 号：R774.1[医药卫生—眼科]