放疗联合TP方案化疗综合治疗食管癌100例临床分析  

Clinical analysis of radiation therapy combined with TP chemotherapy for esophageal cancer

作　　者：万志龙[1] 葛琴[1] 成国建[1] 杭达明[1] 朱琪伟[1] 季秀珍[1] 

机构地区：[1]南通大学附属肿瘤医院放疗科,江苏南通226361

出　　处：《现代肿瘤医学》2010年第12期2378-2379,共2页Journal of Modern Oncology

摘　　要：目的:探讨食管癌放疗加TP方案化疗综合治疗的可行性和近期疗效。方法:200例诊断为中晚期食道癌患者随机分组,综合治疗组应用放疗加化疗100例:紫杉醇135mg/m2静滴,d1,DDP 30mg/m2,静滴,d1-3,休息1周后采用6MVX射线常规分割,前后对穿和等中心斜野照射。DT2Gy/次,5次/周,总量DT60-70Gy,6-7周。单纯放射治疗组100例,放疗方法同综合组。结果:吞咽症状、临床改善情况:综合组为88%,单放组为68.0%,两组差异有显著性意义(P<0.05)。近期疗效:综合组为89.1%,单放组为67.0%,(P<0.05)。放射治疗和药物的不良反应:综合组略高于单放组,但耐受。生存率:综合组1、2、3年生存率分别为63%、50%、39%较单放组54.0%、42%、30%为高。P<0.05。结论:放射治疗加TP化疗综合组疗效优于单放组,值得临床研究。Objective：To evaluate the feasibility and efficacy of radiation therapy combined with TP chemotherapy for esophageal cancer.Methods：Total of 200 advanced esophageal carcinoma patients were randomized into two groups.100 patients in combined group received chemoradiotherapy：paclitaxel 135mg/m2,d1;DDP30mg/m2,d1-3,and received radiotherapy a week later.All patients were irradiated 2Gy per fraction,five fractions a week,the total dose was 60-70Gy/6-7w.Results：The clinical improvement in the combined group was 88% and 68.0% in the radiotherapy only group（P 0.05）.Short-term effect in the combined group was 89.1% and 67.0% in the radiotherapy only group（P 0.05）.The acute toxic effect was sevre in combined group than in radiotherapy only group.The 1,2,3-year survival rate were 63%,50%,39% in the combined group,and 54%,42%,30% in the radiotherapy only group,（P 0.05）.Conclusion：The result of radiotherapy combined TP chemotherapy was more effective than radiotherapy alone in the treatment of esophageal cancer.

关 键 词：食管癌 放疗 化疗 疗效 

分 类 号：R735.1[医药卫生—肿瘤]