Snail、E-cadherin在膀胱尿路上皮癌中的表达及其与膀胱癌复发的关系  

Expression of Snail and E-cadherin in bladder urothelial carcinoma and their relation with tumor recurrence

作　　者：张墨[1] 单立平[1] 张辉[1] 宋永胜[1] 

机构地区：[1]中国医科大学附属盛京医院泌尿外科,辽宁沈阳110004

出　　处：《现代肿瘤医学》2010年第12期2422-2425,共4页Journal of Modern Oncology

摘　　要：目的:研究膀胱尿路上皮癌中Snail与E-cadherin的表达,并探讨其与膀胱癌复发的关系。方法:应用免疫组化方法,检测40例膀胱尿路上皮癌组织和20例癌旁组织中Snail、E-cadherin的表达情况,并分析与临床病理资料的关系。结果:膀胱尿路上皮癌组织中Snail的阳性率(80%)显著高于癌旁组织(45%)(P<0.05),Snail的表达与膀胱尿路上皮癌不同临床分期、病理分级、肿瘤数量、远处转移及复发有关(P<0.05);膀胱尿路上皮癌组织中E-cadherin的阳性率(27.5%)显著低于癌旁组织(65%)(P<0.05),E-cadherin的表达与膀胱尿路上皮癌不同临床分期、病理分级、肿瘤数量及远处转移有关(P<0.05)。膀胱尿路上皮癌组织中Snail与E-cadherin的表达呈负相关(P<0.05)。结论:Snail高表达及E-cadherin低表达与膀胱尿路上皮癌的浸润和转移密切相关,Snail有可能作为膀胱尿路上皮癌复发的重要生物学标志。Objective：To investigate the expression of Snail and E-cadherin in bladder urothelial carcinoma and evaluate their relationships with tumor recurrence.Methods：Immunohistochemical method was used to detect the expression of Snail and E-cadherin proteins in 40 cases of bladder urothelial carcinoma tissue and 20 cases of the para-cancerous mucosa.Results：The positive rate of Snail in bladder urothelial carcinoma was 80%,which was significantly higher than that in para-cancerous mucosa（45%,P 0.05）.The expression of Snail was significantly related with the differential clinical stage,pathological degree,tumor quantity,distant metastasis and tumor recurrence（P 0.05）.The positive rate of E-cadherin in bladder urothelial carcinoma was 27.5%,which was significantly lower than that in para-cancerous mucosa（65%,P 0.05）.The expression of E-cadherin was significantly related with the differential clinical stage,pathological degree,tumor quantity and distant metastasis（P 0.05）.There was negative correlation between expression of Snail and E-cadherin in bladder urothelial carcinoma.Conclusion：The high expression of Snail and low expression of E-cadherin in bladder urothelial carcinoma are involved in the processes of invasion and metastasis of bladder urothelial carcinoma.Snail might be important biological marker for recurrence of bladder urothelial carcinoma.

关 键 词：SNAIL蛋白 E-CADHERIN蛋白 膀胱尿路癌 复发 免疫组化 

分 类 号：R737.14[医药卫生—肿瘤]