骨原发恶性纤维组织细胞瘤的临床病理分析  

A clinicopathological analysis of primary malignant fibrous histiocytoma(MFH) of bone

作　　者：文艳华[1] 裘秀春[1] 张殿忠[1] 马琼[1] 胡薇[1] 刘云燕[1] 赵艳立[1] 杨连甲[1] 

机构地区：[1]第四军医大学唐都医院骨肿瘤研究所,陕西西安710038

出　　处：《现代肿瘤医学》2010年第12期2453-2455,共3页Journal of Modern Oncology

摘　　要：目的:采用新的WHO软组织与骨肿瘤分类标准,对过去已诊断为原发于骨的恶性纤维组织细胞瘤/未分化多形性肉瘤(MFH/UPS)进行回顾性评估,并对重新诊断的MFH/UPS的病理特点、组织学来源及分化方向进行初步探讨,以提高本病的病理诊断水平。方法:收集了16例过去被病理学诊断为原发于骨的MFH病例,用HE染色方法及选用神经特异性、肌特异性、脂肪、纤维、上皮等特异或相对特异性抗体进行免疫组织化学方法,由2位病理医生重新阅片,参照新标准并结合染色结果独立诊断。结果:16例病例中,重新诊断为向恶性神经鞘瘤分化者6例,向横纹肌和平滑肌肉瘤分化5例,不能明确分化5例,其中炎症性恶性纤维组织细胞瘤1例。结论:恶性纤维组织细胞瘤/多形性未分化肉瘤是一复杂且有争议的肿瘤家族,应当引起重视的是发生在骨内的MFH,除了排除其它肉瘤的可能,还应考虑向骨肉瘤分化的可能。Objective：Based on the latest WHO concept about tumours of soft tissue and bone,study the data of 16 cases previously malignant fibrous histiocytoma（MFH）.Methods：Thirteen cases were analyzed retrospectively by HE staining and immunohistochemistry.Results：Among 16 cases,11 cases of MFH were rediagnosed,including 6 malignant peripheral nerve sheath tumors,5 rhabdomyosarcomas or leiomyosarcomas,1 inflammatory malignant fibrous histiocytoma.The remaining 5 cases were finally diagnosed as MFH/UPS.Conclusion：MFH/UPS is a complex tumor family,should pay attention to primary malignant fibrous histiocytoma（MFH） of bone,in addition to ruling out the possibility of other sarcoma,which must be distinguished from osteosarcoma.

关 键 词：恶性纤维组织细胞瘤 骨肿瘤 免疫组化 病理诊断 

分 类 号：R738.1[医药卫生—肿瘤]