镁和偏头痛发病机制的研究  

A study on magnesium and migraine pathogenesis.

作　　者：罗盛[1] 苏闻[1] 高平[1] 胡汉成[2] 王新德[1] 

机构地区：[1]北京医院神经内科,100730 [2]北京医院卫生部临床检验中心,100730

出　　处：《中国神经精神疾病杂志》1999年第4期193-194,共2页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的　了解镁与偏头痛发病机制的关系。方法　检测偏头痛发作患者及健康对照组手术后或肿瘤疼痛（ 疼痛组） 患者血清镁和红细胞镁水平，同时给予偏头痛患者静脉注射潘南金（ Ｄ Ｌ门冬氨酸钾镁） 并观察其反应。结果　偏头痛患者较健康对照组及疼痛组血清镁和红细胞镁均明显降低。经潘南金治疗后具有较低血清镁（ ＜ ０ ．７６ ｍ ｍｏｌ／ Ｌ） 及红细胞镁（ ＜１３５ ｍ ｍｏｌ／ Ｌ） 水平的偏头痛患者症状缓解较血清镁（ ≥０７６ ｍ ｍｏｌ／ Ｌ） 及红细胞镁（ ≥１３５ ｍ ｍｏｌ／ Ｌ） 水平较高的偏头痛患者缓解明显。结论　血液中镁的浓度对偏头痛发作起着重要作用，并参与发病机制。通过补充镁可缓解偏头痛发作的疼痛。s Objective To understand the role of magnesium in migraine pathogenesis.Methods the levels of total serum magnesium and erythrocyte magnesium in patients with an acute attack of migraine headache ,postoperative or neoplastic pain subjects and normal control subjects were measured. At the same time, the response of patients with migraine headache to an intravenous infusion of Panangin (DL Potassium magnesium aspratate) was observed. Results Migraine subjects had significantly lower levels of total serum magnesium and erythrocyte magnesium compared with normal control subjects and other pain subjects. After treatment by Panangin, migraine subjects with lower level serum magnesium (<0.76 mmol/L) and erythrocyte magnesium(<1.35 mmol/L) had significantly more relief than those with higher levels of serum magnesium(≥0.76 mmol/L) and erythrocyte magnesium (≥1.35 mmol/L).Conclusions Magnesium has the core of reaction in building threshold of migraine attacks and may play a role in pathogenesis of migraine attacks. Pain of migraine can be relieved by the administration of magnesium.

关 键 词：镁 偏头痛 发病机制 治疗 

分 类 号：R747.202[医药卫生—神经病学与精神病学]