肺大细胞癌的临床与病理分析  

Analysis of the clinical characteristics and the pathology of large cell lung cancer

作　　者：吕福东[1] 张海清[1] 严红[1] 

机构地区：[1]北京市胸部肿瘤结核病医院病理科

出　　处：《中华结核和呼吸杂志》1999年第7期401-403,共3页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：目的探讨肺大细胞癌临床特点和病理分型。方法对１９７８～１９９７年手术切除的５４例肺大细胞癌的病理资料与临床资料进行了分析。结果５４例大细胞癌中有透明细胞癌６例，巨细胞癌１例。男女之比为５∶１（４５／９），男性明显多于女性；肺大细胞癌占肺癌切除病例的１２８％；平均存活时间为２３个月，Ｐ５３蛋白过度表达，阳性率为６５％（１３／２０），介于鳞癌、腺癌与小细胞癌之间，增殖细胞核抗原（ＰＣＮＡ）免疫组化染色阳性率为１００％（２０／２０）。结论肺大细胞癌作为一种病理类型，已不利于临床的诊断及治疗，建议将肺大细胞癌分成鳞分化型、腺分化型、神经内分泌型、未分化型。Objective To study the clinical characteristics and the pathology of large cell lung cancer (LCLC). Methods Comparing the microscopic and immunohistochemical findings with clinical data by analyzing 54 cases of surgically treated LCLC from 1978 to 1997. Results There were 6 cases of clear cell carcinoma and one case of giant cell carcinoma in 54 cases. Malefemale was 51(45/9). LCLC accounted for 1.28% of all surgically treated lung cancers. The average survival time was 23 months. The positive rate of P53 protein expression was 65%(13/20). The positive rate of PCNA staining was 100%(20/20). Conclusions LCLC may be divided into squamous type, adenomatous type, neuroendocrine type and undifferentiated type.

关 键 词：肺肿瘤 肺大细胞癌 预后 病理学 诊断 

分 类 号：R734.202[医药卫生—肿瘤]