非小细胞肺癌术后残端复发的放射治疗  

Radiation therapy for bronchial stump recurrence of non-small cell lung cancer after complete resection

作　　者：单娟[1] 袁翎[1] 刘新菊[1] 

机构地区：[1]河南省肿瘤医院放疗科,河南郑州450003

出　　处：《中国现代医学杂志》2010年第1期114-115,119,共3页China Journal of Modern Medicine

摘　　要：目的评价和分析非小细胞肺癌术后残端复发行放射治疗的疗效及影响预后的因素。方法28例根治术后残端复发的患者行放疗,剂量为55～70Gy/6～8周,复发均经病理证实,其中伴有淋巴结转移者15例。结果82.1%患者症状缓解:完全缓解35.7%(10/28),部分缓解46.4%(13/28)。1、3和5年生存率分别是75.0%(21/28)、35.7%(10/28)和14.3%(4/28)。残端癌合并淋巴结转移患者中位生存时间为8个月,1年生存率60.0%(9/15),3、5年生存率0%。放疗剂量>60Gy者疗效好于<60Gy者。结论放射治疗是治疗非小细胞肺癌术后残端复发安全有效的重要手段。是否伴有淋巴结转移是影响预后的主要因素。放疗剂量与局部控制率显示存在剂量反应效应,有待进一步证实。【Objective】To evaluate the effect of radiotherapy and the prognosis of stump recurrence in non-small cell lung cancer after radical operation. 【Methods】 28 NSCLC patients with bronchial stump recurrence were treated radiation therapy,the doses of radiation were 55～70Gy/6～8 W. 28 patients were confirmed by histopathology,18 patients had stump recurrence with lymph node metastasis. 【Results】Symptom relief rate was 82.1%：Ten of 28 （35.7%） patients showed a complete response,and thirteen of 28 （46.4%） patients showed a partial response.1-,3-,5-year survival rates were 75%,35.7%,14.3%. Median survival time of 15 patients with mediastinal lymph nodes were 8 months,1-year survival rates was 60%,3-,5-year survival rates were 0%.Patients who received radiotherapy with DT 〉60Gy had a better survival rate and than those with DT 〈60Gy.【Conclusion】Raditherapy was an effective and safe tool in the treatment of bronchial stump recurrent NSCLC after curative resection. Without/with lymph node metastasis was the affected faction to survival. It seemed there was a dose-response effect in this patients and observation had an implication for future studies.

关 键 词：非小细胞肺癌 放疗 残端复发 

分 类 号：R734.2[医药卫生—肿瘤]