延边地区2型糖尿病患者ACEI/D基因多态性与颈动脉IMT的相关性研究  

Study on correlation between insertion/deletion ACE gene polymorphism and carotid IMT in patients with Type 2 diabetes mellitus in Yanbian district

作　　者：金青松[1] 朴莲善[1] 郑寿焕[1] 文英玉[1] 李美子[1] 金京玉[1] 金红梅[1] 

机构地区：[1]延边大学附属医院内分泌科,吉林延吉133000

出　　处：《中国现代医学杂志》2010年第3期392-394,399,共4页China Journal of Modern Medicine

基　　金：国家自然科学基金(No:30460053)

摘　　要：目的研究ACEI/D基因多态性在延边地区汉族与朝鲜族群体中的分布特征及与2型糖尿病颈动脉IMT之间的相关性。方法正常对照组(汉族、朝鲜族);2型糖尿病组:①汉族2型糖尿病颈动脉硬化阳性组及阴性组;②朝鲜族2型糖尿病颈动脉硬化阳性组及阴性组。采用PCR-RFLP方法。结果①汉族ACEI/D多态性分布特征为Ⅱ36.9%、ID34.0%、DD29.1%;朝鲜族分布特征为Ⅱ31.5%、ID39.1%、DD29.3%。②ACE基因多态性在汉族与朝鲜族2型糖尿病及其动脉硬化阳性组与阴性组间差异无显著性。结论ACEI/D基因多态性在延边地区汉族和朝鲜族群体中的分布无种族差异;且与延边地区汉族和朝鲜族2型糖尿病患者的颈动脉硬化无相关性。【Objective】To study the distribution of ACE I/D gene polymorphism in Han and Korean population in Yanbian district of China and the correlation between ACE I/D gene polymorphism and carotid IMT in Patients with Type 2 Diabetes Mellitus in Yanbian district.【Methods】Normal control group（Han and Korean nationality）;T2DM group：T2DM patients with and without carotid atherosclerosis in Han nationality;T2DM patients with and without carotid atherosclerosis in Korean nationality.Assess the NAD（P） H oxidase P22phox C242T polymorphism by PCR-RFLP analysis.【Results】The ACE I/D genotype of Han population of Yanbian area were Ⅱ（36.9%）,ID（34.0%）,DD（29.1%）;the ACE I/D genotype of Korean population of Yanbian area were Ⅱ（31.5%）,ID（39.1%）,DD（29.3%）.There is no significant difference in the ACE I/D gene polymorphism between Han and Korean nationality in T2DM patients whether with or without carotid atherosclerosis.【Conclusion】There is no racial difference on ACE I/D gene polymorphism between Han and Korean population in Yanbian district.And ACE I/D gene polymorphism have no correlation with carotid atherosclerosis in both Han and Korean T2DM patients in Yanbian district.

关 键 词：延边地区 2型糖尿病 ACEI/D基因多态性 颈动脉硬化 

分 类 号：R363.25[医药卫生—病理学] R587.1[医药卫生—基础医学]