细胞凋亡与高血压脑出血患者血管破裂的相关性  

THE ASSOCIATION OF APOPTOSIS WITH VASCULAR RUPTURE IN PATIENTS WITH HYPERTENSIVE INTRACEREBRAL HEMORRHAGE

作　　者：曹相军[1] 李庭福[2] 周铁军[3] 彭俊[1] 张明伟[1] 

机构地区：[1]泸州医学院附属中医院神经外科,四川泸州646000 [2]泸州医学院附属中医院检验科,四川泸州646000 [3]泸州医学院病理教研室,四川泸州646000

出　　处：《泸州医学院学报》2010年第6期614-616,共3页Journal of Luzhou Medical College

基　　金：四川省卫生厅资助项目(No:80174)

摘　　要：目的:探讨高血压脑内出血患者血管破裂的发生机理。方法:正常脑血管,高血压脑出血患者出血部位的脑动脉分别进行TUNEL染色,计数血管平滑肌细胞凋亡比例。结果:高血压脑出血患者血管平滑肌细胞凋亡百分比为70.00±2.60,正常脑血管平滑肌细胞凋亡百分比为14.29±2.60。结论:血管平滑肌细胞凋亡与高血压脑内出血患者相关。Objective：To study the mechanism of blood vessel rupture in patients with hypertensive in tracerebral hemorrhage.Methods：TUNEL staining and counting of apoptosis percentage in vascular smooth muscle cells were carried out in normal and hypertensive intracerebral hemorrhage growps.Results： In hypertensive cerebral hemorrhage,vascular smooth muscle cell apoptosis was 70.00 ± 2.60%;in normal brain,vascular smooth muscle cell apoptosis was 14.29 ± 2.60%.Conclusion： Apoptosis of vascular smooth muscle cells was associated with hypertensive intracerebral hemorrhage.

关 键 词：凋亡 脑内出血 血管平滑肌细胞 

分 类 号：R743.34[医药卫生—神经病学与精神病学]