胸苷磷酸化酶在膀胱尿路上皮癌中的表达及预后价值  

Cfinical pathological and prognostic significance of thymidine phosphorylase in bladder urothefial carcinoma.

作　　者：赵伟[1] 孙茸[1] 赵守国[1] 赵南[1] 

机构地区：[1]聊城市人民医院,山东聊城252000

出　　处：《中外医学研究》2010年第28期10-12,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的探讨胸苷磷酸化酶（TP）在膀胱尿路上皮癌的表达及临床意义，评价TP预后价值。方法采用免疫组化的方法检测54例膀胱癌组织及15例正常膀胱组织的TP表达，通过回顾性随访，以TP表达水平、I临床病理变量及2个预后变量[无复发生存率（RFS）和总生存率（OS）]为研究对象，探讨它们之间关系，绘制生存曲线。结果TP在54例肿瘤组织的阳性率为57．41％（31／54），TP表达水平与膀胱癌的分级、分期、复发及患者死亡无关。15例正常膀胱尿路上皮未见TP表达。经生存分析，TP不同表达水平的患者复发和死亡无明显差异。结论肿瘤细胞的TP表达与膀胱癌的临床病理及预后无关，但它在肿瘤组织中特异高表达，这可能有助于膀胱癌早期诊断、复发检测及探讨新的治疗方法。Objective To investigate the expression of thymidine phosphorylase （TP） in bladder urothelial carcinoma and their corre- lation with prognosis. Methods The expression of TP was assessed by immunohistochemistry on 54 bladder urothelial carcinoma and 15 nor- mal bladder specimens, and all these patients were retrospectively investigated after surgery. Cfinicopathologic findings and two prognostic vari- ances including relapse - free survival （RFS） and overall survival （OS） were determined. The prognostic value of TP was estimated by surviv- al curve. Results Thirty - one of 54 cases （57.41% ） were TP positive. There was no correlation between the expression of TP and grade, stage,recurrence or survival. There was no TP expression in 15 cases of normal bladder tissues. There was significant difference in the expression of TP between bladder urothelial carcinoma tissueg and normal bladder tissues （ P = 0.00）. Kaplan - Meier analysis demonstrated that patients with TP positive had no significantly different prognosis compared to patients with TP negative. Conclusion The TP expression of tumor cell was independent with elinicopathology and prognosis. But high TP expression in tumor cell may help early diagnosis of bladder urothelial carcinoma, recurrence test and approach of new therapeutic method.

关 键 词：膀胱尿路上皮癌 胸苷磷酸化酶 预后 

分 类 号：R737.14[医药卫生—肿瘤]