原发性肝癌患者肝切除术后血浆MMP-2和TIMP-2浓度变化及生长抑素干预  

The concentration changes and intervention of somatostatin of MMP-2 and TIMP-2 of plasma after hepatectomy in patients with hepatocellular carcinoma

作　　者：龚时文[1] 袁崇德[1] 唐俊丽[1] 简建文[1] 骆松辉[1] 王金林[1] 游志坚[1] 区庆嘉[2] 

机构地区：[1]广东省东莞市人民医院外科,523018 [2]中山大学二院外科,510120

出　　处：《岭南现代临床外科》2010年第1期11-12,共2页Lingnan Modern Clinics in Surgery

基　　金：广东省医学科研基金课题(编号:A2004772)

摘　　要：目的观察肝癌患者肝切除后血浆MMP-2和TIMP-2浓度变化及生长抑素干预。方法20例肝癌切除患者随机分成2组,常规治疗组和生长抑素治疗组,每组各10例,生长抑素治疗组给于生长抑素治疗。结果肝切除后,血浆MMP-2浓度明显上升,血浆TIMP-2浓度明显下降,应用SST能降低MMP-2浓底,升高TIMP-2浓度。Objective To observe concentration changes and intervention of somatostatin of MMP-2 and TIMP-2 of plasma after hepatectomy in patients with liver cancer.Methods Twenty cases received hepatectomy were randomly divided into teo groups namely conventional therapeutic group and somatostatin treatment group.Ten cases were in each group.The somatostatin was given in the somatostatin treatment group.Results The plasma concentration of MMP-2 was significantly increased and The plasma concentration of TIMP-2 was significantly decreased after hepatectomy.The administration of somatostatin could decrease the plasma concentration of MMP-2 and increase the plasma concentration of MMP-2.Conclusions The administration of somatostatin after hepatectomy might suppress of recurrence after surgery.

关 键 词：肝癌 生长抑素 MMP-2 TIMP-2 

分 类 号：R735.7[医药卫生—肿瘤]