结肠癌中微血管形成的定量检测及临床意义  

Quantitative determination of Tumor Angiogenesis in Colon Cancer and Its Clinical Significance

作　　者：苏树英[1] 陈凤兰[1] 钟广益[1] 彭翔[1] 姚旻[1] 

机构地区：[1]广东省佛山市第一人民医院 [2]上海第二医科大学附属第九人民医院

出　　处：《中国医师杂志》1999年第2期27-28,共2页Journal of Chinese Physician

摘　　要：定量研究结肠癌微血管形成与肿瘤侵袭转移和预后的关系。选择７６例结肠癌手术切除标本，应用抗ＣＤ３４单克隆抗体免疫组化ＡＢＣ法对肿瘤组织的微血管进行染色，定量分析微血管数与结肠癌侵袭转移及病人预后的关系。结肠癌组织的微血管数随肿瘤的发展（ＴＮＭ分期）而增加，已发生血行转移的癌肿的微血管数高于区域淋巴转移和无淋巴转移者。对其中５８例有随访资料的病人分析表明，微血管数较高的结肠癌病人的５年生存率显著地低于微血管数较低病人。微血管数定量是判断结肠癌侵袭转移和预后的一个指标。The relationship among microvessel counts,invasive metastasis and prognosis of colon cancer were investigated.We also examined survival rate of seventy-six patients with colon carcinoma,all of them uderwent tumor resection during 1985～1992 year in china.Microvessel density in endothelial cells of tumor tissue in each section was assessed by immunohistochemical staining with anti-human CD34 monoclonal antibody.The results showed:⑴The highest density in tumor area was found.⑵The microvessel counts of metastatic tumors were significantly higher than those of nonmetastatic ones.The increased microvessel count was accorded with TNM staging,which reflecting tumor progression.Microvessel count was significantly higher in stage Ⅳ tumor than that in stage Ⅰ tumor.⑶Five-year survival rate was 52.6% for patients in hypermicrovascular group,The difference was significant between the two groups.The data suggest that the microvessel count might predict metastasis and prognosis of colon cancer.High metastasis and poor prognosis maybe occur more frequently in those patients with hypermicrovascular count.

关 键 词：结肠癌 血管形成 肿瘤转移 

分 类 号：R735.350.7[医药卫生—肿瘤]