原发性肝癌患者肝动脉栓塞化疗前后肝纤维化指标的变化  

The change related to the fibrotic indicators of primary hepatic carcinoma Patients ther transcatheter arterial embolization

作　　者：王天才[1] 谌辉[1] 李善高[1] 梁扩寰[1] 

机构地区：[1]同济医科大学附属同济医院肝病研究所,武汉430030

出　　处：《胃肠病学和肝病学杂志》1999年第1期50-51,共2页Chinese Journal of Gastroenterology and Hepatology

摘　　要：探讨重复肝动脉栓塞化疗（ＴＡＥ）是否加重肝癌患者肝硬化的形成。方法我们对４０例经三次．ＴＡＥ治疗的原发性肝癌（ＰＨＣ）患者，测定了治疗前后透明质酸（ＨＡ）、层粘蛋白（ＬＮ）、人ｉｌｌ型前胶原（ｈｐｅⅢ）和四型胶原（Ⅳ．Ｃ）的含量。结果首次ＴＡＥ治疗后与ＴＡＥ前相比，上述四项指标差异无显著性意义（Ｐ＞０．０５）；从第二次ＴＡＥ治疗后，可见四项肝纤维化指标均有升高（Ｐ＜０．０５），以第三次ＴＡＥ后升高最为明显（Ｐ＜０．０１）。结论重复ＴＡＥ治疗常可加重患者的肝损害，应引起足够的重视。Aims To investigate whether transcatherter arterial elnbolization (TAE) can aggravate the fonnation ofcirrhosis of patients with primary hepatic careinoma (PHC) .Method We had determined the contents of serum procollagentype-Ⅲ (bpc-Ⅲ ), collagen type-W (Ⅳ C), hyaluronate acid(HA) and laminin (LN) of 40 patients with PHC who had received hoe times cushion of TAn. ReSult No remarkable significance came out in relation to the four indicators of patentsbefore and after the curation of TAE. But, compared to those before curation of TAE, the four fibrotic indicators rose significantly (P < 0. 05 ) after the second curation of TAE. Furthermore, these indicators rose more after the thick curation of TAn (P < 0.01). COncluSion The repeated curation of TAn could intensify damage of the liver, to which should be paid more attention.

关 键 词：肝动脉 肝癌 肝纤维化 栓塞治疗 

分 类 号：R735.705[医药卫生—肿瘤]