血清BAFF、APRIL水平与原发性胆汁性肝硬化的关系  

Elevated serum levels of BAFF and APRIL associated with primary biliary cirrhosis

作　　者：朱晓琳[1] 马世武[1] 胡小雄[1] 贺玉凯[2] 侯金林[1] 朱幼芙[1] 

机构地区：[1]南方医科大学附属南方医院,广州510515 [2]聊城市人民医院

出　　处：《山东医药》2010年第49期1-3,共3页Shandong Medical Journal

基　　金：国家自然科学基金项目(30730082);南方医院院长基金项目(2009C009)

摘　　要：目的探讨血清中B细胞刺激因子(BAFF)和增殖诱导配体(APRIL)水平与原发性胆汁性肝硬化(PBC)的关系。方法选择PBC、慢性乙型肝炎(CHB)患者和健康献血者(HC)各12例,采用ELISA法检测血清中BAFF和APRIL的表达水平。结果 PBC组血清BAFF水平明显高于CHB组(P=0.008)和HC组(P=0.012),但ARPIL水平在三组间差异无统计学意义。血清BAFF水平与谷草转氨酶呈正相关(r=0.391,P=0.020),与血清白蛋白呈负相关(r=-0.434,P=0.017);血清APRIL水平与患者年龄呈正相关(r=0.551,P=0.002),与血清白蛋白呈负相关(r=-0.424,P=0.039)。结论 PBC患者血清BAFF水平明显升高,并与肝脏损害程度相关。Objective To investigate the relationship between the serum levels of B-cell activation factor（BAFF） or a proliferation-inducing ligand （APRIL） and the disease severity of primary biliary cirrhosis （PBC）. Methods The clinical data were collected from 12 cases of PBC, chronic hepatitis B （CHB） , healthy control （HC） , respectively. The serum levels of BAFF and APRIL were assayed by ELISA. Results The serum levels of BAFF in patients with PBC were signifi- cantly higher than those in patients with CHB（ P = 0. 008） and HC controls （P = 0.012 ）. While there was no significant difference among the three groups on the profile of APRIL levels. There was a significant correlation between serum BAFF levels and AST （r =0.391 ,P =0.020） or ALB （r= -0.434, P=0.017）, and the APRIL levels correlated with ages （r = 0.551 ,P = 0.002） or ALB （r = - 0.424,P = 0.039）. Conclusions The serum levels of BAFF significantly elevate in patients whith PBC and associate with the severity of liver injury.

关 键 词：肝硬化 B细胞刺激因子 增殖诱导配体 

分 类 号：R575.1[医药卫生—消化系统]