血管紧张素转化酶基因I/D多态性与高血压脑梗塞发病的相关性  

Relationship between angiotensin-converting enzyme gene polymorphism and hypertension disease complicated with brain infarction

作　　者：杜明艳[1] 封靖[1] 周桔[2] 丁文军[2] 

机构地区：[1]北京潞河医院神经内科,北京101149 [2]中国科学院研究生院生命科学学院,北京100049

出　　处：《中国科学院研究生院学报》2010年第6期778-781,共4页Journal of the Graduate School of the Chinese Academy of Sciences

摘　　要：采用PCR方法分别检测82例高血压合并脑梗塞患者(BI)、67例单纯高血压患者(EH)和95例健康对照者(C)的血管紧张素转化酶(ACE)基因I/D多态性类型,并分析ACE基因I/D多态性分布与高血压合并脑梗塞发病的相关性.结果显示,BI组ACE基因的D/D基因型频率和D等位基因频率(分别为0.341和0.524)显著高于C组(分别为0.200和0.374,P<0.05)和EH组(分别为0.179和0.358,P<0.05),而EH组和C组ACE基因的D/D基因型频率和D等位基因频率无显著性差异.该研究结果表明,ACE基因的D/D基因型可能是高血压合并脑梗塞发病的独立危险因素.The angiotensin-converting enzyme （ACE） gene I /D polymorphism was detected in 82 cases of brain infarction （BI）,67 cases of simple essential hypertension （EH）,and 95 normal cases （control）.The relationship between the gene polymorphism and the hypertension disease complicated with brain infarction was evaluated.The frequencies of ACE D /D genotype and D allele （0.341 and 0.524） in the BI group were significantly higher than those in the control group （0.200 and 0.374,P〈0.05） and EH group （0.179 and 0.358,P〈0.05 ）.The results suggest that ACE-DD variant may be significantly relevant to Chinese hypertensive patients with brain infarction.

关 键 词：血管紧张素转化酶 基因多态性 高血压 脑梗塞 

分 类 号：R743[医药卫生—神经病学与精神病学]