CD44v6和MMP9在子宫内膜癌中表达的研究  

Expression of CD44v6 and MMP9 in Endometrial Carcinoma Cell Tissuse

作　　者：付秋风[1] 熊勇[1] 孙丽萍[1] 秦贇娜[1] 于晓红[1] 

机构地区：[1]江西省妇幼保健院,南昌330006

出　　处：《实用中西医结合临床》2010年第6期70-72,共3页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨CD44v6、MMP9在子宫内膜癌中表达的意义。方法:采用免疫组织化学ElivisionPlus法对78例子宫内膜癌中CD44v6和MMP9表达进行检测及分析。结果:CD44v6和MMP9的表达与子宫内膜癌病理分级、临床分期无关,与淋巴结转移有关。结论:CD44v6、MMP9在淋巴结转移过程中起着重要作用,有助于早期预测转移潜能,判断预后及指导术后干预治疗。Objective：To detect the expression of CD44v6 and MMP9 protein in endometrial carcinoma.Methods：The expression of CD44v6 and MMP9 were detected by immunohistochemical method in 78 cases of endometrial carcinoma.Results：The expression of CD44v6 and MMP9 were neither correlated with pathological grading nor clinical stages;its expression was up-expressed in the case of lymph node metastasis.Conclusion：CD44v6 and MMP9 playing the important roles in the lymph node metastasis,it could help to predict the metastasis potentidlity on the early phase,estimate the prognosis and direct the interference therapy after operation.

关 键 词：CD44V6 MMP9 子宫内膜癌 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]