超声波催化合成N^3-苄基喹唑啉类化合物  

Synthesis of N^3- Benzylquinazolin-4-one under Ultrasonic Irradiation

作　　者：王鹏[1] 张树华[2] 田亮[1] 王建国[1] 宗光喜[1] 刘刚[1] 

机构地区：[1]鲁东大学化学与材料科学学院,山东烟台264025 [2]桓台县田庄中学,山东淄博256402

出　　处：《广州化工》2010年第11期97-99,共3页GuangZhou Chemical Industry

基　　金：山东省高等学校科技计划项目(J10LA58);鲁东大学引进人才基金(LY20062905;LZ20082902);鲁东大学2010年大学生科技创新基金和鲁东大学创新团队建设项目(No.08-CXB001)资助

摘　　要：以喹唑啉-4-酮和溴苄为原料,在超声波辐射催化下,相转移催化两相合成N3-苄基喹唑啉-4-酮,化合物经IR和1HNMR确证了其结构。实验表明,超声波辐射催化下能大大提高反应产率,降低反应时间,比传统条件下产率提高25%左右;离子液体[Bmim]PF6也能较大幅度的提高反应产率,但与超声波一同使用,会有一定的拮抗作用。N3-Benzylquinazolin-4-one was synthesized using quinazolin-4-one and bromobenzyl as starting materials under ultrasonic irradiation and phase transfer catalysis in biphasic system.The structure of the compound was characterized by IR and 1H NMR.The results of experiments showed that the yield increased greatly and the reaction time was shorted under ultrasonic irradiation.The yield increased about 25% more than the yield of traditional conditions.The yield increased greatly in [Bmim]PF6 catalysis also.However,it had antergic effect with ultrasonic used together.

关 键 词：喹唑啉 超声波 合成 离子液体 

分 类 号：TQ655[化学工程—精细化工]