信号转导和转录激活因子3与妇科恶性肿瘤研究进展  

Research Progress of Signal Transducer and Activator of Transcription 3 and Gynecological Malignant Tumour

作　　者：王卡娜[1] 辛亚兰[2] 张建[1] 郄明蓉[1] 

机构地区：[1]四川大学华西第二医院,四川成都610041 [2]兰州大学第二医院妇产科

出　　处：《中华妇幼临床医学杂志（电子版）》2010年第6期437-442,共6页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：四川省科技厅科研项目(04JY029-077-2)~~

摘　　要：信号转导和转录激活因子(signal transducer and activatorof transcription,STAT)3是信号转导与转录活化因子家族重要成员,作为JAK-STAT(Janus kinase signal transducer and activator of transcription)途径中JAK的底物,接受生长因子与细胞因子等细胞外信号刺激激活。活化的信号转导和转录激活因子3蛋白进入细胞核,结合靶基因,修饰靶基因的表达,从而调节细胞增殖、分化及凋亡。研究表明,信号转导和转录激活因子异常激活可通过抑制凋亡,促进细胞增殖等促进细胞恶性转化与进展。多种人类恶性肿瘤中均存在信号转导与转录活化因子家族成员的异常激活。通过阻断该途径,能抑制肿瘤细胞增殖,促进细胞凋亡。JAK-STAT信号转导途径,可参与妇科恶性肿瘤发生发展。随着对信号转导和转录激活因子3更深入研究,可能为妇科恶性肿瘤的早期诊断及预后提供线索,并为卵巢癌等妇科恶性肿瘤的耐药及治疗提供新靶点。Signal transducer and activator of transcription （STAT） 3 is an important member of signal transducer and activator of transcription（STATs）, which was originally identified as a substrate of the Janus kinase（JAK） in Janus kinase-signal transducer and activator of transcription （JAK-STAT） pathway. It has been demonstrated to receive growth factors and cytokines or other extracellular stimulation. Activated signal transducer and activator of transcription proteins translocate to the nucleus to regulate expression of genes by binding to specific elements within gene promoters, then to regulate tumor- cell proliferation, differentiation and apoptosis. Abnormal activation of the signal transducer and activator of transcription family members have been found in a large group of human malignant tumors. Researches show that abnormal activation of signal transducer and activator of transcription 3 can inhibit apoptosis, thereby promoting tumovcell proliferation, invasion and metastasis. Instead, by blocking the way, it could inhibit the tumor-cell proliferation and induce apoptosis of cancer cells. Increasing domestic and foreign evidences demonstrate that JAK-STAT pathway may be involved in the oncogenesis of gynecological malignant tumor. With further researches, signal transducer and activator of transcription 3 may provide clues for early diagnosis and prognosis of gynecological malignant tumor, and may provide a new target for therapy, especially for ovarian cancer drug resistance.

关 键 词：信号转导和转录激活因子3 妇科恶性肿瘤 JAK STAT通路 分子靶向抑制 

分 类 号：R737.3[医药卫生—肿瘤]