奥扎格雷对急性缺血性卒中患者微栓子及C反应蛋白的影响  

Influence of ozagrel on micro embolic signal and C reactive protein in patients with acute cerebral infarction

作　　者：黄志东[1] 顾承志[1] 黄国祥[1] 黄怀宇[1] 

机构地区：[1]南通大学第二附属医院,江苏南通226001

出　　处：《现代中西医结合杂志》2010年第36期4655-4656,4681,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：南通市社会发展计划项目(2008014)

摘　　要：目的探讨奥扎格雷对急性缺血性卒中患者微栓子及C反应蛋白的影响。方法将50例微栓子监测阳性患者随机分为治疗组、对照组各25例。治疗组给予奥扎格雷80mg加入0.9%氯化钠液500 mL静脉滴注,2次/d;对照组给予丹参注射液20 mL加入0.9%氯化钠液250 mL静脉滴注,1次/d。观察2组治疗前后患者微栓子数和血浆C反应蛋白的变化。结果治疗2周后,治疗组患者微栓子数和血浆C反应蛋白较治疗前显著下降(P均<0.01),而对照组下降不明显,2组比较有显著性差异(P<0.05)。结论奥扎格雷具有降低微栓子数和血浆C反应蛋白的作用,从而减轻炎症反应和降低血小板的活化,改善脑梗死部位缺氧缺血和缺损神经功能。Objective It is to approach the influence of ozagrel on micro embolic signal（MES） and C reactive protein（CRP） in patients with acute cerebral infarction.Methods Fifty cases with MES were randomly divided into two groups with 25 cases each group.The therapy group was received sodium ozagrel 80 mg intravenous drip twice a day for two weeks;the control group was received Danshen injection 20 mL intravenous drip once a day for two weeks.Before and after treatment,the levels of CRP and MES were determined.Results The levels of CRP and MES were significantly decreased in the therapy group（P〈0.01）,and the control group without any change.There was significantly difference between both groups（P〈0.05）.Conclusion Ozagrel can decrease the number of MES and CRP in patients with acute cerebral infarction,so to lighten the inflammation reaction,reducing the activation of blood platelet and improve prognosis.

关 键 词：奥扎格雷 急性缺血性卒中 微栓子 C反应蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学]