恶性肿瘤患者凝血功能检测的临床意义  

Clinical significance of coagulation functions detection in patients with malignant tumor

作　　者：赵晶[1] 游舟[1] 李曾[1] 

机构地区：[1]四川省肿瘤医院内科,四川成都610041

出　　处：《四川生理科学杂志》2010年第4期161-162,共2页Sichuan Journal of Physiological Sciences

摘　　要：目的:研究肺癌、乳腺癌、食道癌、胃癌、肝癌及肾癌等恶性肿瘤患者的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、血小板计数(PLT)的变化并探讨其临床意义。方法:检测恶性肿瘤患者的PT、APTT、FIB和PLT,并与健康体检者的上述指标进行对照。结果:肝癌、肾癌组患者的PT,肝癌、肾癌、肺癌及食道癌组患者的APTT较健康对照组显著延长,差异有统计学意义(P<0.05);FIB含量除肝癌组外,其他各肿瘤组均显著高于健康对照组,差异有统计学意义(P<0.05);PLT在乳腺癌、肺癌、胃癌组显著增高,肝癌组显著低于健康对照组,差异有统计学意义(P<0.05)。结论:与对照组相比,恶性肿瘤患者的PT、APTT时间显著延长,PLT数量及FIB含量增高,是发生血栓性疾病的高危人群,对肿瘤患者进行适当抗凝药物的使用有助于减少血栓性疾病的发生并降低远处转移的机会。Objective：To investigate the alterations of platelet count and plasma levels of coagulation markers in patients with malignant tumors and explore their clinical significance.Methods： The plasma levels of coagulation markers and platelet count were detected in 107 patients with malignant tumors and in 35 normal controls.Results： Compared with the normal controls,the plasma levels of prothrombin time in patients with liver cancer and kidney cancer and active partial thromboplastin time in patients with liver cancer,kidney cancer,lung cancer and esophagus cancer were higher（P0.05）.The plasma level of fibrinogen of all patients except liver cancer was significantly higher than those of the normal controls（P0.05）.The platelet count was significantly higher in patients with breast cancer,stomach cancer and lung cancer and was significantly lower in patients with liver cancer（P0.05）.Conclusion： To patients with malignant tumors,the plasma levels of prothrombin time and active partial thromboplastin time were higher and the plasma levels of fibrinogen and the platelet count rised.The anticoagulant medicine use may reduce the chance of thrombosis and metastatic spread of some types of cancer.

关 键 词：恶性肿瘤 凝血酶原时间 活化部分凝血活酶时间 纤维蛋白原 血小板计数 

分 类 号：R730.4[医药卫生—肿瘤]