肿瘤-睾丸抗原与肺癌  

Cancer-testis antigens and lung cancer

作　　者：徐瑛(综述)[1] 周彩存(审校)[1] 

机构地区：[1]同济大学附属上海市肺科医院肿瘤科,200433

出　　处：《国际肿瘤学杂志》2010年第12期916-919,共4页Journal of International Oncology

摘　　要：肿瘤-睾丸抗原（CTA）在正常睾丸组织的生殖细胞及多种不同组织类型的癌细胞中特异表达.研究证明CTA表达与肺癌的分期、病理类型、复发、转移等密切相关,且在肺癌患者中有抗原性免疫反应.应用CTA对肺癌开展免疫治疗表现出良好的前景.Cancer-testis antigens （CTAs） are protein antigens with normal expression restricted to adult testis and yet are aberrantly activated and expressed in a proportion of various types of tumor tissues. The expressions of CTA correlate with tumor staging, histopathological subtype, recurrence and metastasis in nonsmall cell lung cancer. CTAs are immunogenic in lung cancer patients and have a good prospect in lung cancer Immunotherapy.

关 键 词：肺肿瘤 抗原 免疫疗法 

分 类 号：R735.7[医药卫生—肿瘤]