乳腺癌间质成纤维细胞α-SMA表达的意义  

The significance of α-SMA expression in interstitial fibroblasts of breast cancer

作　　者：徐继[1] 张岩[1] 何治军[1] 

机构地区：[1]江苏省连云港市第二人民医院肿瘤科,222023

出　　处：《重庆医学》2010年第23期3195-3196,3199,共3页Chongqing medicine

摘　　要：目的探讨乳腺癌间质成纤维细胞α-平滑肌肌动蛋白(α-CSMA)在乳腺癌浸润机制中的作用以及与乳腺癌预后的关系。方法通过免疫组化的方法检测α-SMA在乳腺癌及正常乳腺组织间质中的表达,结合5年随访资料分析α-SMA表达与浸润性导管癌预后的关系。结果α-SMA在原位癌间质成纤维细胞和早期浸润性导管癌表达阳性率分别为12.5%(2/16),42.9%(9/21),两者差异有统计学意义(P<0.05);α-SMA在浸润性导管癌间质与原位癌及早期浸润癌表达差异均有统计学意义(P<0.01)。在浸润性导管癌中,α-SMA在Ⅲ期、Ⅳ期表达阳性率高于Ⅰ期、Ⅱ期,差异有统计学意义(P<0.05)。对68例浸润性导管癌进行生存分析,α-SMA表达阴性组5年生存率高于α-SMA表达阳性组,两者差异有统计学意义(P<0.05)。结论α-SMA与乳腺癌浸润机制有一定关系,可能是影响乳腺癌预后的因素之一。Objective To research α-SMA of interstitial fibroblasts action in the mechanism of the role of invasive breast cancer as well as the relationship between the prognosis of breast cancer.Methods By immunohistochemistry to detect α-SMA in breast cancer and normal breast tissue expression of interstitial.Combination of 5-year follow-up data analysis,the relationship between α-SMA expression and prognosis in breast invasive ductal carcinoma.Results α-SMA in interstitial fibroblasts of DCIS and Early invasive ductal carcinoma positive expression rate was 12.5%（2/16）,42.9%（9/21）,between the two was statistically significant（P〈0.05）.α-SMA in invasive ductal carcinoma with DCIS and early invasive carcinoma were statistically significant（P〈0.01）.In the invasive ductal carcinoma,α-SMA in stage Ⅲ,Ⅳ period of positive expression rate was higher than in stage Ⅰand Ⅱ,there are statistically significant（P〈0.05）.Of 68 cases of infiltrating ductal carcinoma in survival analysis,α-SMA negative expression of 5-year survival rate was higher than the expression of α-SMA positive group.Are statistically significant difference between the two（P〈0.05）.Conclusion α-SMA and breast cancer invasion mechanisms have a certain relationship,which may affect the prognosis of breast cancer one of the factors.

关 键 词：Α-平滑肌肌动蛋白 成纤维细胞 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤] R730.43[医药卫生—临床医学]