短时间高强噪声对豚鼠听器的影响  

Effect of Short Time Highintensity Noise on Hearing Organ in Guinea Pigs.TBZ

作　　者：何延军[1] 李道德[1] 郑素贤[1] 

机构地区：[1]航天医学工程研究所

出　　处：《航天医学与医学工程》1999年第3期217-219,共3页Space Medicine & Medical Engineering

摘　　要：目的为研究高强噪声对豚鼠听功能的影响。方法２４只豚鼠随机分成对照、１１５ｄＢ（Ａ）暴露和１１８ｄＢ（Ａ）暴露三组，每组８只。观察分析了粉红噪声暴露３ｍｉｎ，豚鼠的鼓膜、毛细胞及听力的变化。结果耳镜检查两暴露组鼓膜无明显损伤；但两暴露组都出现了明显的暂时性听阈偏移（ｔｅｍｐｏｒａｒｙｔｈｒｅｓｈｏｌｄｓｈｉｆｔ，ＴＴＳ）；耳蜗铺片观察两暴露组都发现了毛细胞损伤（Ｐ＜０．０１）。两暴露组的ＴＴＳ３０ｍｉｎ内没有恢复到暴露前水平。与１１５ｄＢ（Ａ）暴露组相比，１１８ｄＢ（Ａ）组毛细胞损伤更严重，ＴＴＳ增大更明显（Ｐ＜０．０５）。Objective To investigate the effects of high-intensity noise on hearing organ. Methods 24 guinea pigs were randomly divided into three groups(8 each): normal control group,115 dB(A) noise exposure group and 118 dB(A) noise exposure group. Changes of eardrum, hair cell and hearing threshold were observed in guinea pigs after 3 minute exposure to 115 dB(A) and 118 dB(A) pinknoise level. Result (1) No obvious damage of eardrum was found in both two noise exposure groups with otoscopy; but obvious temporary threshold shift (TTS) of hearing was observed in both groups;(2) Significant damage of hair cell was observed in both exposure groups by morphological analysis of the cochlea( P <0.01);(3) TTS in both exposure groups didn't recover to the preexperiment level within half an hour;(4) TTS and damage of hair cell were more severe in 118 dB(A) noiseexposure group than those in 115 dB(A) group ( P <0.05). Conclusion Short time 115 dB(A) noise exposure can cause damage on hearing organ.

关 键 词：噪声 豚鼠 听力 暂时性听阈偏移 听器损伤 

分 类 号：R852.24[医药卫生—航空、航天与航海医学]