癌相关通路在肺腺癌中的共扰动机制  

The co-dysregulations of cancer related pathways in lung adenocarcinoma

作　　者：朱晶[1] 沈晓沛[1] 肖会[1] 张杨[1] 王靖[1] 郭政[1,2] 

机构地区：[1]电子科技大学生命科学与技术学院生物信息学中心,成都610054 [2]哈尔滨医科大学生物信息科学与技术学院,哈尔滨150086

出　　处：《生物信息学》2010年第4期291-294,共4页Chinese Journal of Bioinformatics

基　　金：国家自然科学基金30670539;国家自然科学基金30770558

摘　　要：肺腺癌的发生涉及多个生物学功能通路的扰动,其遗传改变频繁地发生于MAPK信号、p53信号、Wnt信号、细胞周期和mTOR等通路的基因中。解析癌相关通路间的共扰动机制对我们理解癌机制以及寻找诊断标记具有重要意义。因此,本文基于肺腺癌突变谱数据,研究上述癌相关通路在肺腺癌中的共扰动机制。结果发现:在肺腺癌发生的过程中,MAPK信号、p53信号、Wnt信号、细胞周期和mTOR等通路同时被扰动。在不同的癌样本中,一对通路可能通过以下三种方式被共同扰动:(1)在两条通路中的不同基因间的共突变;(2)两条通路相互交叠基因的突变;(3)与两条通路同时具有频繁的互作关系的蛋白质的编码基因的突变。该结果提示,癌相关通路对在不同的样本中可能通过不同的方式被共扰动,这也可能是造成癌症异质性的重要原因之一。The initiation of lung adenocarcinoma involves the disruption of multiple functional pathways.The mutation frequently happened to the gene in MAPK,p53,Wnt cell cycle and mTOR signal pathway etc.The analysis of co-dysregulations of cancer related pathways plays an important role for us to understand the mechanism of cancer and find markers.Based on the somatic mutation data of lung adenocarcinoma,we studied the co-dysregulations of cancer related pathways.Our results show that during the process of lung adenocarcinoma,MAPK,p53,Wnt,cell cycle and mTOR signal pathway are co-disregulated.A pair of pathways might be co-disregulated by three means：（1） co-mutation of genes between two pathways;（2） mutation of overlap gene between two pathways;（3） mutation of gene whose encoding protein significantly interacting with 2 pathways.The resultes suggest that cancer related pathways can be co-dysregulations by different ways and this might be a concernful reason for heterogeneity of cancer.

关 键 词：肺腺癌 基因突变 信号通路 蛋白质互相作用 

分 类 号：Q811.4[生物学—生物工程]