拟南芥花药基因的共表达分析  

Analyse Gene Co-expression in Arabidopsis Anther

作　　者：焦清局[1] 刘太岗[2] 郑小琪[3] 连爱娥[1] 黄继风[1] 

机构地区：[1]上海师范大学计算机科学与技术系,上海200234 [2]大连理工大学数学科学学院,辽宁大连116024 [3]上海师范大学数理学院,上海200234

出　　处：《生物信息学》2010年第4期350-355,共6页Chinese Journal of Bioinformatics

基　　金：上海市教育委员会教育科学研究资助项目(批准号:07ZZ60)

摘　　要：运用图论中最大团算法,对ATTED-Ⅱ数据库中提供的拟南芥共表达数据进行分析,为进一步研究基因功能提供了较为可靠的数据。文中提出的算法首先根据芯片数据鉴定拟南芥花药基因,然后以ATTED-Ⅱ数据库为基础构建每一个花药基因的共表达网络,最后利用最大团算法从共表达网络中挖掘共表达数据。基于这种方法,系统地分析了每一个拟南芥花药基因的共表达情况,有助于拟南芥花药发育分子机理和基因转录调控的深入研究。实验验证这种方法对拟南芥花药共表达基因的提取十分有效。In the present paper,we analyze the co-expression data of Arabidopsis thaliana from ATTED-Ⅱ database based on the Maximum-clique algorithm in graph theory,and obtain more reliable data for the further study of gene function.In the first step,we identified the anther expressed genes using gene-chip data,and then constructed their co-expression networks based on the pairwise gene coexpression coefficients provided by ATTED-Ⅱ.Finally,we mined co-expressed data from the co-expression networks with Maximum-clique algorithm.Using the method,we completely analyzed every gene co-expression in Arabidopsis anther.This research in this paper may facilitate further investigation of the molecular mechanisms of anther and transcription regulation.Experimental validation results on extracting co-expressed genes from Arabidopsis anther demonstrate that the proposed method exhibits good performance.

关 键 词：拟南芥 花药 共表达 最大团 ATTED-Ⅱ数据库 

分 类 号：Q[生物学]