使用ASTM方法检验2%氯己定皮肤消毒剂长效抑菌效果的研究  

Persistent Antimicrobial Efficacy of 2% Chlorhexidine Skin Disinfectant by ASTM Test Method

作　　者：林林[1] 李宇[1] 谢颖玮[1] 沈颖[1] 

机构地区：[1]3M中国有限公司,上海200233

出　　处：《中华医院感染学杂志》2010年第24期3942-3944,共3页Chinese Journal of Nosocomiology

摘　　要：目的评估2%葡萄糖酸盐氯己定皮肤抑菌效果。方法根据英国测试和材料协会(ASTM)相关测试方法,对18名受试者在用氯己定皮肤消毒前、消毒后10 min、1、2、5、7 d后分别进行采样培养,检测消毒效果。结果消毒前菌落数均值2.15 Log10CFU/ml,消毒后10 min、1、2、5、7 d的采样均值为0.41、0.61、0.79、1.02、1.49Log10CFU/ml,均低于基线水平(P<0.01)。结论 2%葡萄糖酸盐氯己定经ASTM方法检测具有7 d抑菌效果。OBJECTIVE To assess persistent antimicrobial efficacy of 2% chlorhexidine skin disinfectant.METHODS American Society for Testing and Materials（ASTM） test was used to assess the baseline,10 min,dd 1,2,5 and 7 after the disinfection of chlorhexidine skin disinfectant.The antimicrobial efficacy of the skin was checked out.RESULTS The skin flora of baseline was 2.15 Log10 while the average values of 10 min,dd 1,2,5 and 7 after skin disinfectant were 0.41,0.61,0.79,1.02 and 1.49 Log10,respectively,all were below the baseline（P0.01）.CONCLUSION The 2% chlorhexidine skin disinfectant has a 7 day persistent antimicrobial efficacy after the determination by ASTM test.

关 键 词：皮肤消毒剂 抑菌 氯己定 

分 类 号：R187.2[医药卫生—流行病学]