4750例抗结核药品不良反应分析  

Analysis on 4750 Adverse Drug Reaction Cases of Anti-tuberculosis Drugs

作　　者：冯红云[1] 陈易新[1] 

机构地区：[1]国家食品药品监督管理局药品评价中心,北京100045

出　　处：《中国药物警戒》2010年第12期751-754,共4页Chinese Journal of Pharmacovigilance

基　　金：中国全球基金第一轮结核病项目实施性研究(TB07-030)

摘　　要：目的了解抗结核药品不良反应的一般情况及对结核病患者的危害程度,为指导临床合理用药提供参考。方法检索某时间段国家药品不良反应监测中心病例报告数据库中抗结核药品的不良反应报告资料,并进行统计分析。结果各年龄组均有不良反应发生,不良反应主要累及肝胆系统,多发生在用药后50天以内,预后较好。结论为保障结核病治疗的有效进行,临床医生要熟悉抗结核药品的常见不良反应,及时发现并处理不良反应,尽可能有效地减少抗结核药品不良反应的严重后果。Objective To investigate the general conditions and harm to patients of anti-tuberculosis drugs,and to provide informations for rational administration.Methods The adverse drug reaction（ADR） cases of antituberculosis drugs in national ADR monitoring database were retrieved and analyzed statistically.Results There were ADR of anti-tuberculosis drugs were in every age group.The ADR of anti-tuberculosis drugs involved liver and gall system,happened in 50 days after medication,and the prognosis of anti-tuberculosis drugs ADR was well.Conclusion In order to ensure the effective anti-tuberculosis treatment,clinicians should be familiar with the common ADR of anti-tuberculosis drugs,detect and deal with the ADR of anti-tuberculosis drugs in time,and reduce possibly the severity.consequence of the ADR of anti-tuberculosis drugs.

关 键 词：药品不良反应 抗结核药品 国家药品不良反应数据库 

分 类 号：R978.3[医药卫生—药品] R994.11[医药卫生—药学]