首发抑郁症患者甲状腺功能相关因素探讨  

An exploration of thyroid function in patients with first episode depression

作　　者：杨睿[1] 魏子坤[1] 武雯[1] 白晓英[1] 谢志椽[1] 王翔[1] 

机构地区：[1]陕西西安市中心医院,710003

出　　处：《临床精神医学杂志》2010年第6期374-376,共3页Journal of Clinical Psychiatry

基　　金：陕西省科学技术研究发展计划项目[(2007K15-7301(18)];西安市科技计划项目(YF07143)

摘　　要：目的:探讨首发抑郁症患者甲状腺功能的特点及甲状腺功能与生活事件、抑郁焦虑情绪的关系。方法:对30例未用药的首发抑郁症患者(研究组)和30名健康志愿者(对照组)进行甲状腺激素(血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)、促甲状腺素(TSH)、抗甲状腺过氧化物酶抗体(Anti-TPO)、抗甲状腺球蛋白抗体(Anti-Tg)水平测定;并以汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、生活事件量表(LES)及自动思维量表(ATQ)进行评定。结果:两组HAMD总分、HAMA总分、ATQ总分、LES负性分及LES总分比较,差异均有统计学意义(P均=0.000);正性生活事件刺激量两组间差异无统计学意义(P=0.898)。两组FT3、FT4、T3、T4、TSH、Anti-TPO及Anti-Tg水平比较,差异无统计学意义(P均>0.05)。研究组负性生活事件刺激量与Anti-TPO及Anti-Tg正相关(r=0.366、0.376;P<0.05),生活事件总刺激量与Anti-Tg正相关(r=0.370,P<0.05),正性生活事件刺激量与FT4正相关(r=0.391,P<0.05)。结论:抑郁症患者可能存在免疫功能异常,免疫功能异常与负性生活事件的刺激强度有很大关系。Objective：To study the characteristic of thyroid function in patients with first episode depression and the relationship of thyroid function connected with life events,depression and anxiety. Method：Thirty drug naive patients with first episode depression and 30 healthy controls were tested for thyroid free triiodothyronine （FT3）,free thyroxine （FT4）,triiodothyronine （T3）,thyroxine （T4）,thyrotropin（TSH）,antithyroid peroxidase antibody （Anti-TPO）,antithyroglobulin antibody （Anti-Tg）,Hamilton depression scale （HAMD）,Hmailton anxiety scale（ HAMA）,life events scale（LES） and automatic thoughts questionnaire（ATQ）were also tested. Results：There was significantly difference between patients with first depression and normal subjects in HAMD total score,HAMA total score,ATQ total score,LES negative score and LES total score（all P=0.000）.The amount of positive life events stimulation was no significant difference between the two groups（P=0.898）.There was no significant difference between patients with first depression and normal subjects in FT3,FT4,T3,T4,TSH,Anti-TPO,Anti-Tg（P0.05）.There were positive correlations between the quantities of stimulus of negative life events and Anti-TPO,Anti-Tg in patients with first depression（r=0.366,0.376;P0.05）.There were positive correlations between total quantity of stimulus of life events and Anti-Tg（r=0.370,P0.05）.There were positive correlations between the quantity of stimulus of positive life events and FT4（r=0.391,P0.05）. Conclusion：There may be immune dysfunction in patients with depression.Immune dysfunction is significantly related with the quantity of stimulus of negative life events.

关 键 词：抑郁症 甲状腺功能 甲状腺激素 

分 类 号：R749.4[医药卫生—神经病学与精神病学]