淫羊藿总黄酮对高脂血症大鼠血脂水平的影响  

Effect of Total Flavonoids of Epimedium on Blood Lipid in Hyperlipidemia Rat

作　　者：蔡辉[1] 徐佳杨[1] 赵智明[1] 

机构地区：[1]南京军区南京总医院中西医结合科,南京210002

出　　处：《南昌大学学报（医学版）》2010年第9期4-6,10,共4页Journal of Nanchang University：Medical Sciences

摘　　要：目的探讨淫羊藿总黄酮(TFE)对高脂血症大鼠总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平的影响。方法将40只SD大鼠按随机数字表法分为普通饲料组(9只)和高脂饲料组(31只)。高脂饲料组大鼠喂以高脂饮食12周后检测空腹血脂,26只造模成功。随机又分为3组,模型组(8只)、淫羊藿大剂量组(9只,淫羊藿200 mg灌胃,1次.d-1,连续4周)及淫羊藿小剂量组(9只,淫羊藿100 mg灌胃,1次.d-1,连续4周),16周后检测血脂水平。结果干预前,高脂饲料组大鼠血清中的TG、TC以及LDL-C水平均高于普通饲料组(均P<0.01),HDL-C与普通饲料组比较差异无统计学意义(P>0.05)。干预4周后,模型组的TG、TC水平均明显高于普通饲料组(均P<0.01);淫羊藿大剂量组及淫羊藿小剂量组的TG、TC水平明显低于模型组(P<0.05或P<0.01);淫羊藿大、小剂量组对LDL-C、HDL-C水平的影响比较差异均无统计学意义(均P>0.05)。结论 TFE能够降低高脂血症大鼠TG、TC水平。Objective To investigate the effect of total flavonoids of epimedium（TFE） on total cholesterol（TC）,triglyeride（TG）,high density lipoprotein cholesterol（HDL-C） and low density lipoprotein cholesterol（LDL-C） in blood plasm of hyperlipidemia rats.Methods 40 male SD rats were randomly devided into the high-fat diet group（31） and the full diet group（9）.High fat diet group were fed with high-fat diet（HF） for 12 weeks,then the blood lipid were detected,which indicated that 26 of them had established the model of hyperlipidemia rat.Then the 26 male SD rats were randomly devided into three groups：the hyperlipidemia group（8）,hyperlipidemia group with a large dose of TFE（9,lavaged with TFE 200 mg,1 d-1,for 4 weeks）,and hyperlipidemia group with a small dose of TFE（9,lavaged with TFE 100 mg,1 d-1,for 4 weeks）.At the 16th week,respectively,serum lipid level was measured in the rats.Results Compared with the full diet group,the levels of TG,TC,LDL-C in high-fat diet group were significantly increased（all P〈0.01） before intervention,while the level of HDL-C has no statistical significance（P〉0.05）.The levels of TG and TC in hyperlipidemia group were higher than the full diet group（both P〈0.01） after intervention.Compared with the hyperlipidemia group,both of the levels of TC and TG in hyperlipidemia group with large dose of TFE and small dose of TFE were obviously lower（P〈0.05 or 0.01）,while the levels of LDL-C and HDL-C has no statistical significance（P〉0.05）.Conclusion TFE can reduce the levels of TC and TG in hyperlipidemia rats.

关 键 词：淫羊藿总黄酮 高脂血症大鼠 血脂 动物 实验 大鼠 

分 类 号：R-332[医药卫生]