成纤维细胞生长因子研究进展  

Advance in research of FGF8

作　　者：葛玉强[1] 邓春梅[1] 林运鸿[1] 刘丽[1] 

机构地区：[1]福建省发育与神经生物学重点实验室福建师范大学生命科学学院,福建福州350108

出　　处：《现代生物医学进展》2010年第22期4380-4382,共3页Progress in Modern Biomedicine

摘　　要：成纤维细胞生长因子8(fibroblast growth factor 8,FGF8)是成纤维细胞生长因子家族的成员之一,是动物组织器官发育过程中重要的分泌性调控因子。在胚胎发育的早期,FGF8广泛表达。它可以介导胚胎期的上皮和间充质的转化,在原肠的形成,早期器官如前后脑、咽、心脏、生殖器官和指等的形成和分化中都起到关键性的作用。本文就FGF8在器官发育中的作用及其研究进行概述。Fibroblast growth factor 8 （fibroblast growth factor 8, FGF8） is one of the fibroblast growth factor family member, and an important secreted regulatory factors during the development of of the tissues and organs of animals. FGF8 is widely expressed during embryonic development. It has been shown to mediate embryonic epithelial-mesenchymal transition and to have a crucial role in gastrulation and early organization and differentiation of midbrain/hindbrain, pharyngeal, cardiac, urogenital and limb structures. This review focused on the role FGF8＇s in organ development and it＇s research.

关 键 词：成纤维细胞生长因子8(FGF8) 器官发育 

分 类 号：R78[医药卫生—口腔医学]