急性脑卒中与血脂及颈动脉粥样硬化斑块的相关性分析  

Association study between plasma lipid,carotid artherosclerosis and acute stroke

作　　者：张留福[1,2] 朱幼玲[1,2] 汪国宏[1,2] 

机构地区：[1]安徽医科大学第三附属医院 [2]合肥市第一人民医院神经内科

出　　处：《中国临床药理学与治疗学》2010年第9期1056-1059,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:研究急性脑卒中(脑出血、脑梗死)与血脂的关系,并探讨脑梗死患者颈动脉粥样硬化斑块形成与血脂代谢异常的相关性。方法:选择安徽省合肥地区急性脑卒中患者670例(脑出血172例、脑梗死498例)与118名健康对照者,检测血脂和颈动脉粥样硬化斑块情况。结果:脑梗死组TC、TG、低密度脂蛋白胆固醇(LDL-C)水平显著高于对照组(P<0.01,P<0.01,P<0.01)。脑出血组血清TC水平显著高于对照组(P<0.01)。脑梗死组斑块检出率为51.4%(256/498),显著高于对照组的15.3%(18/118)(P<0.01),脑梗死组斑块阳性检出者较脑梗死组斑块阴性检出者血脂异常率显著升高(P<0.01)。脑梗死组斑块阳性检出者TG(P<0.01)、TC(P<0.01)、LDL-C(P<0.01)水平明显高于脑梗死组斑块阴性检出者,而高密度脂蛋白胆固醇(HDL-C)水平明显低于脑梗死组斑块阴性检出者(P<0.05)。结论:血清TC、TG、LDL-C水平升高与脑梗死发病相关;血清TC水平升高与脑出血发病相关;颈动脉粥样硬化斑块的形成与血脂水平异常密切相关,并且是脑梗死发病的一个重要危险因素。个体优化调脂治疗在脑卒中的二级预防中具有重要意义。AIM：To investigate the association between plasma lipid and acute cerebral accident,evaluate the correlation between abnormal lipid metabolism and arteria carotis atherosclerotic in cerebral infarction. METHODS： The concentration of plasma lipid was detected in 172 cerebral hemorrhage patients,498 cerebralinfarction patients and 118 healthy controls.And arteria carotis atherosclerotic plaque was detected in all cerebral infarction patients and healthy controls.RESULTS：The TC,TG,LDL-C levels in cerebral infarction patients were significantly higher than those in control.The TC levels in cerebral hemorrhage patients were significantly higher than those in control.The incidence of carotid atherosclerotic plaque in cerebral infarction patients was significantly higher than that in control（P0.01）.The incidence of lipid metabolic disturbance was significantly rising in cerebral infarction patients with positive incidence of carotid atherosclerotic plaque compared with negative incidence of carotid atherosclerotic plaque（P0.01）.The TG,TC,LDL-C levels in cerebral infarction patients with positive incidence of carotid atherosclerotic plaque were significantly increased as compared with negative incidence of carotid atherosclerotic plaque.CONCLUSION： High plasma TC,TG and LDL-C showed associated with cerebral infarction.Plasma TC showed associated with cerebral hemorrhage.There is a close correlation between carotid atherosclerotic plaque and lipid metabolic disturbance.Carotid atherosclerotic plaque is an important risk factor for cerebral infarction.

关 键 词：脑梗死 脑出血 血脂 颈动脉粥样硬化斑块 调脂治疗 

分 类 号：R743[医药卫生—神经病学与精神病学]