家兔脑干三叉神经诱发电位监测方法的研究  

Study of method for monitoring brain-stem trigeminal evoked potentials in rabbits

作　　者：洪文瑶[1] 李世亭[1] 

机构地区：[1]上海交通大学医学院附属新华医院神经外科上海交通大学颅神经疾病诊治中心,200092

出　　处：《中国微侵袭神经外科杂志》2010年第11期519-521,共3页Chinese Journal of Minimally Invasive Neurosurgery

基　　金：上海市科委重点项目(编号:074119630);上海市教委曙光计划基金资助项目(编号:07SG21)

摘　　要：目的建立稳定可靠的家兔脑干三叉神经诱发电位的监测方法。方法 20只家兔随机分为两组,每组各10只。两组均使用针形刺激电极,一组穿刺鼻唇沟(穿刺鼻唇沟组),另一组穿刺眶下孔(穿刺眶下孔组),均以Cz-Cv7导联记录家兔三叉神经诱发电位。结果两组刺激阈值和最大刺激强度均无明显差别;穿刺眶下孔组三叉神经诱发电位波形检出率明显高于穿刺鼻唇沟组(χ2=6.6667,P<0.01),但刺激产生的肌电伪迹较明显。结论穿刺眶下孔直接刺激眶下神经能够较恒定地监测出三叉神经诱发电位,尽管伪迹较明显,但不影响对波形特征的判断,应用价值较大。Objective To establish a stable and reliable monitoring method for brain-stem trigeminal evoked potentials in rabbits.Methods Twenty rabbits were randomly and equally assigned to two groups.Needle-shaped stimulation electrodes were used in both groups.The nasolabial groove was punctured （nasolabial group） in one group,while the infraorbital foramen done in the other group （infraorbital group）.The potentials were recorded by Cz-Cv7 leads.Results The stimulus threshold and maximum stimulus intensity were not significantly different between the groups.Detection rate of trigeminal evoked potentials was significantly higherin infraorbital group than in nasolabial group （χ2 = 6.666 7,P 0.01）,but more obvious stimulus artifacts were elicited from the muscle.Conclusions Puncture of the infraorbital foramen to directly stimulate infraorbital nerve can constantly elicit trigeminal evoked potential,despite obvious muscles stimulus artifacts,which does not affect the analysis of waveform characteristics.Therefore,this method is more practical in rabbit experiments.

关 键 词：诱发电位 三叉神经 脑干 监测方法 鼻唇沟 眶下孔 兔 

分 类 号：R745.11[医药卫生—神经病学与精神病学]