结直肠癌组织中生长抑素受体亚型的表达与血管生成的关系  

Relationships Between Expressions of Somatostatin Receptor Subtypes and Angiogenesis in Colorectal Cancer

作　　者：邱成志[1] 黄种心[2] 吴友谊[1] 邱建龙[2] 

机构地区：[1]福建医科大学附属第二医院普外科,福建泉州362000 [2]福建医科大学附属第二医院病理科,福建泉州362000

出　　处：《中国普外基础与临床杂志》2010年第11期1164-1167,共4页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的探讨生长抑素受体(SSTR)的5种亚型(SSTR1～SSTR5)在结直肠癌组织中的表达与血管生成的关系。方法免疫组化染色法(SP法)检测127例结直肠癌组织中SSTR1～SSTR5、血管内皮生长因子(VEGF)及CD34的表达并计算微血管密度(MVD),分析SSTR各亚型的表达与VEGF表达及MVD的关系。结果结直肠癌组织中SSTR1、SSTR2、SSTR3、SSTR4及SSTR5表达阳性率分别为64.6%(82/127)、36.2%(46/127)、18.9%(24/127)、18.9%(24/127)及38.6%(49/127),VEGF表达阳性率为63.8%(81/127),MVD为(34.67±16.62)个/HP。SSTR2呈阳性表达的结直肠癌组织中VEGF的表达阳性率(47.8%,22/46)及MVD〔(29.00±15.32)个/HP〕明显低于呈阴性表达者〔72.8%,59/81;(37.90±16.56)个/HP〕,P<0.05;而其他4种亚型的表达与VEGF的表达及MVD无关(P>0.05)。结论结直肠癌组织中SSTR2的阳性表达与血管生成有关。Objective To study the relationships between expressions of somatostatin receptor subtypes（SSTR1-SSTR5）and angiogenesis in colorectal cancer.Methods The expressions of SSTR1-SSTR5,VEGF,and CD34in the paraffin sections of colorectal cancer tissues from 127cases were detected by the standard streptavidin-peroxidase（SP）technique.CD34was used as a marker to account microvessel density（MVD）in colorectal cancer tissues.The relationships between the expressions of SSTR1-SSTR5and VEGF expression,or MVD were analyzed.Results The positive expression rate of SSTR1,SSTR2,SSTR3,SSTR4,and SSTR5was 64.6%（82/127）,36.2%（46/127）,18.9%（24/127）,18.9%（24/127）,and 38.6%（49/127）in colorectal cancer tissues,meanwhile,the positive expression rate of VEGF was 63.8%（81/127）and MVD was（34.67±16.62）/HP in colorectal cancer tissues.The positive expression rate of VEGF（47.8%,22/46）and MVD〔（29.00± 15.32）/HP〕in colorectal cancer tissues with SSTR2positive expression were significantly lower than those in colorectal cancer tissues with SSTR2negative expression〔72.8%,59/81;（37.90±16.56）/HP〕,P0.05.There were no relationships between SSTR1,SSTR3,SSTR4,and SSTR5expression and VEGF expression or MVD（P 0.05）.Conclusion The positive expression of SSTR2is related with angiogenesis in colorectal cancer tissues.

关 键 词：生长抑素受体亚型 结直肠癌 血管生成 免疫组织化学 

分 类 号：R735.34[医药卫生—肿瘤]