Reduced Expression of PTEN Protein and Its Prognostic Significance in the Gastrointestinal Stromal Tumor  

作　　者：张永红 于冬冬 李小兰 胡俊波 龚建平 

机构地区：[1]Tongji Cancer Research Institute,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》2010年第2期165-169,共5页华中科技大学学报（医学英德文版）

基　　金：supported by a grant from 973 program from Ministry of Science and Technology of China (No. 2004CB518705,2009CB521802);the National Natural Science Foundation of China (No. 30872472, 30800569);New Century Eminent Talents (No. NCET-04-0699)

摘　　要：Little is reported about the role of PTEN gene in the progression and prognosis of GISTs. This study examined the clinical implications of the tumor suppressor gene PTEN as a prognostic factor in the GISTs. Immunohistological staining and immunoblotting were employed to examine the PTEN protein expression, and its association with clinical measures. Clinicopathological features were reviewed by a retrospective examination of medical records. Reduced PTEN expression was significantly associated with tumor diameter, mitotic figure count, metastasis and pathological stage of tumor （P〈0.05）, and was not correlated with age, gender and tumor location （P〉0.05）. The 3-year survival rate of the patients with reduced PTEN expression was significantly lower than those with high PTEN expression （P〈0.01）. These results suggest that the expression of PTEN gene was significantly linked with the progression and metastasis of GISTs and it is an independent prognostic factor.Little is reported about the role of PTEN gene in the progression and prognosis of GISTs. This study examined the clinical implications of the tumor suppressor gene PTEN as a prognostic factor in the GISTs. Immunohistological staining and immunoblotting were employed to examine the PTEN protein expression, and its association with clinical measures. Clinicopathological features were reviewed by a retrospective examination of medical records. Reduced PTEN expression was significantly associated with tumor diameter, mitotic figure count, metastasis and pathological stage of tumor （P〈0.05）, and was not correlated with age, gender and tumor location （P〉0.05）. The 3-year survival rate of the patients with reduced PTEN expression was significantly lower than those with high PTEN expression （P〈0.01）. These results suggest that the expression of PTEN gene was significantly linked with the progression and metastasis of GISTs and it is an independent prognostic factor.

关 键 词：gastrointestinal stromal tumor PTEN PROGNOSIS 

分 类 号：R735[医药卫生—肿瘤]