HBV-DNA阳性肝癌患者血清HBeAg检测与肝癌术后预后关系的研究  

Relationship Between the Level of HBeAg and the Prognosis of Hepatocarcinoma Patients with HBV-DNA After Hepatectomy

作　　者：王建国 刘继斌[2] 

机构地区：[1]江苏省邳州东方医院,江苏邳州221300 [2]江苏省南通大学附属肿瘤医院,江苏南通226361

出　　处：《标记免疫分析与临床》2010年第6期353-355,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：研究HBV-DNA阳性肝癌患者血清HBeAg检测与肝癌术后预后的关系。检测HBV-DNA阳性HCC肝切除术患者60例、HBV-DNA阴性HCC肝切除术患者60例术前及术后1周血清HBV-DNA水平,密切观察肝功能变化情况以及检测血清HBeAg水平。结果显示：HBV-DNA阳性组与HBV-DNA阴性组比较,HBV-DNA阳性组中,HBeAg阳性患者为48例,阳性率为80.0%;HBV-DNA阴性组中,HBeAg阳性患者为12例,阳性率为20.0%,二者之间有明显的差异（2χ=43.2,P〈0.05）。HBV-DNA阳性组中,48例HBeAg阳性患者中44例复发或转移,占91.7%;12例HBeAg阴性患者中6例复发或转移,占50.0%;二者之间有明显的差异（2χ=12,P〈0.05）。HBV-DNA阴性组中,12例HBeAg阳性患者中9例复发或转移,占75.0%;48例HBeAg阴性患者中26例复发或转移,占54.2%;二者之间无明显的差异（2χ=1.714,P〉0.05）。HCC肝切除患者生存期1~24个月,中位生存期为11.24个月,其中HBV-DNA和HBeAg双阳性患者中位生存期8.45个月,HBV-DNA和HBeAg双阴性患者中位生存期14.87个月,HBV-DNA阴性组中HBeAg阳性与HBeAg阴性患者中位生存期无明显差别。结论：HBV-DNA阳性肝癌患者血清HBeAg检测对于肝癌术后预后判定有一定价值,尤其是HBV-DNA阳性肝癌患者其HBeAg也是阳性表达的病人,定期检测HBV-DNA拷贝数以及HBeAg的效价对于术后肝癌患者预后生存有一定的现实意义。To investigate the relationship between the expression level of HBeAg and the prognosis of hepatocarcinoma patients with HBV-DNA after hepatectomy,the serum levels of HBeAg and HBV-DNA in 60 hepatocarcinoma patients with HBV-DNA positive and 60 hepatocarcinoma patients with HBV-DNA negative before and one week after hepatectomy were determined.The results showed that there was significantly different（χ2=43.2,P0.05） in serum levels of HBeAg between HBV-DNA positive group and HBV-DNA negative group.The Median Survival Times were significantly different between HCC patients with HBV-DNA positive and which negative by Short-term follow-up（P0.05）.High level of serum HBV-DNA would result in the aggravation of hepatic dysfunction.Detection of the serum levels of HBeAg and serum HBV-DNA could predict the incidence of the prognosis of hepatocarcinoma patients after hepatectomy.

关 键 词：HBV-DNA阳性 肝癌 预后 HBEAG 

分 类 号：R735.7[医药卫生—肿瘤]