氟桂利嗪治疗难治性癫痫有效性及安全性的Meta分析  

Effectiveness and Safety of Flunarizine for Refractory Epilepsy: A Meta-Analysis

作　　者：赵常宝[1] 张建斌[1] 任旭[1] 王素芳[1] 原志军[1] 李晓慧[1] 董红岩[1] 刘晗睿[1] 胡晓雁[1] 段圣杰[1] 

机构地区：[1]长治医学院附属和济医院,长治046000

出　　处：《中国循证医学杂志》2010年第12期1461-1466,共6页Chinese Journal of Evidence-based Medicine

摘　　要：目的评价氟桂利嗪治疗难治性癫痫的有效性及安全性。方法计算机检索中国期刊全文数据库(1994～2010.9)、中国生物医学文献数据库(1978～2010.9)、中文科技期刊全文数据库(1989～2010.9)、中国医学会数字化期刊库(1997～2010.9)、PubMed(1966～2010.9)和Cochrane Library(2010年第9期)等,纳入有关氟桂利嗪添加治疗难治性癫痫的随机对照试验,参照Jadad评分标准评估纳入研究的方法学质量,并提取有效数据进行分析。结果共纳入8个研究,合计545例患者。Meta分析结果显示:在常规治疗基础上,与安慰剂和不治疗相比,氟桂利嗪可以提高成人和小儿难治性癫痫治疗的有效率,且差异有统计学意义,其OR(95%CI)分别为2.98(1.88～4.73)和33.75(4.13～276.00)。氟桂利嗪的主要不良反应有嗜睡、疲乏、头晕、头痛和体重增加,但不良反应除体重增加外主要出现在用药早期,用药一段时间或经减小剂量、对症处理后就会消失或自行缓解。结论目前研究表明氟桂利嗪治疗难治性癫痫有效且安全性较好。Objective To assess the effectiveness and safety of flunarizine for refractory epilepsy.Methods Relevant randomized controlled trials（RCTs） were searched from the database of PubMed,EMbase,Cochrane Library,CNKI,CBM,and VIP,and the related references were traced to obtain the information.The methodological quality of included RCTs was assessed using Jadad scale and meta-analysis was performed using RevMan 5.0 software.Results A total of eight studies involving 545 patients were included.The results of meta-analyses showed that： based on the conventional therapy,compared with placebo and none-treatment,flunarizine was more effective on adults and children with refractory epilepsy（OR=2.98,95%CI 1.88 to-4.73;OR=33.75,95%CI 4.13 to-276.00）.Major adverse events of flunarizine were fatigue,dizziness,headache,and weight gain etc.All those symptoms except for the weight gain were observed in the early stage of medication,which might get self-cured or could disappear by constant medication or reducing the dose or symptomatic treatment.Conclusion The present study shows that based on the conventional therapy,flunarizine is effective and safe for refractory epilepsy.

关 键 词：氟桂利嗪 难治性癫痫 META分析 系统评价 

分 类 号：R742.1[医药卫生—神经病学与精神病学]