多发性骨髓瘤117例血清免疫学特征分析  

The seroimmunological analysis of 117 multiple myeloma cases in xinjiang

作　　者：马慧霞[1] 范淑英[1] 郭淑丽[1] 

机构地区：[1]新疆维吾尔自治区人民医院检验科,新疆维吾尔自治区乌鲁木齐830001

出　　处：《中国基层医药》2010年第22期3073-3074,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的分析多发性骨髓瘤（MM）血清免疫学特征。方法对117例MM患者血清进行血清蛋白电泳、免疫固定电泳、免疫球蛋白（IgG、IgA、IgM）及总蛋白，白蛋白定量分析。结果117例MM患者血清蛋白电泳显示M带67例（57．3％），主要位于1区。免疫固定电泳分型：IgG型62例（53．0％），IgA型19例（16．3％），IgM型12例（10．1％），DL型2例（1．7％），轻链型22例（18．8％）。同型免疫球蛋白含量显著升高并常伴有非对应组分的偏低。血清总蛋白有不同程度的升高和白蛋白一定程度的降低。结论血清免疫学特征综合分析，对MM的诊断分型和临床分期及预后判断具有重要意义。Objective To analyze the immunological feature of the multiple myeloma. Methods The serum of 117 eases were detected by serum protein electrophoresis and immunofixation electrophoresis;and analyzed quantitatively immune globulin（ IgG、IgA 、IgM） , total protein and albumin. Results Monoclone protein peak was found in 67 patients out of 117 patients tested（57.3% ） ,it located mainly at 7 border. Immunoglobulin G was found in 62 patients out of 117 patients tested（53.0% ）. Immunoglobulin A was 19 cases（ 16.3% ） ,Immunoglobulin M was 12 cases（ 10. 1% ） ,DL was 2 cases（ 1.7% ） ,free light chain was 22 cases（ 18.8% ）. Homotypic immunoglobulin level increased notably and non-correspond constituent was low in immunoglobulin test. The protein quantified displayed that total protein increased and albumin decreased in different level. Conclusion The seroimmunological index played a crucial role in diagnois ,clinical stage and prognosis of MM.

关 键 词：多发性骨髓瘤 血蛋白电泳 免疫电泳 

分 类 号：R733[医药卫生—肿瘤]