正电子放射性显像剂代谢及其研究方法进展  

The progress on researching method and metabolism of positron radiopharmaceutical

作　　者：甘红梅[1] 乔晋萍[1] 孔爱英[2] 朱霖[1] 

机构地区：[1]北京师范大学化学学院放射性药物教育部重点实验室,100875 [2]总后卫生部药品仪器检验所,北京100071

出　　处：《国际放射医学核医学杂志》2010年第2期65-72,共8页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家重点基础研究发展计划（973计划）（2006CB500705）项目,国家高技术研究发展计划（863计划）（2006AA02A408）项目

摘　　要：正电子放射性显像剂主要用于PET的研究,能在分子水平上反映细胞代谢、细胞受体活性、细胞核内的核酸合成以及细胞基因的改变,在临床疾病诊断和治疗中有重要的地位和作用.PET显像剂进入生物体内后会发生代谢转化,了解PET显像剂的代谢途径和转化过程,对于准确分析和解释显像结果及设计开发新型PET显像剂非常重要.该文总结了目前PET显像剂代谢研究的现状,并对PET显像剂代谢研究方法以及分析技术等进行了综述.Positron radiopharmaceuticals are mainly used for PET studies, which are used in the field of nuclear medicine as tracers in the diagnosis and treatment of many diseases. They have important position and fuction in the clinical diagnosis and treatment. Metabolism or biotransformation will happen when PET radiopharmaceuticals enter into the body. Understanding the metabolic fate of radio-pharmaceutical probes is essential for an accurate analysis and interpretation of positron emission tomography imaging. The recent research progress on PET radiopharrnaceuticals metabolism was reviewed in this paper, including the metabolism characteristics, research methods, analytical techniques and so on.

关 键 词：正电子发射断层显像术 放射性药物 生物转化 药物代谢 

分 类 号：R[医药卫生]