分化型甲状腺癌患者日尿排泄131I活度分数估算  

Estimation the daily urinary excretion 131I radioactivity of patients with differentiated thyroid carcinoma

作　　者：易艳玲[1] 石洪成[2] 顾宇参[2] 陈波[1] 卓维海[1] 胡鹏程[2] 

机构地区：[1]复旦大学放射医学研究所,上海200032 [2]复旦大学附属中山医院核医学科,上海200032

出　　处：《国际放射医学核医学杂志》2010年第4期226-229,共4页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：基金项目：国家自然科学基金（10675036）

摘　　要：目的 探讨甲状腺切除术后经131I治疗的分化型甲状腺癌（DTC）患者日尿排泄131I活度分数的估算方法.方法 建立优化隔室模型,并计算甲状腺癌患者日尿排泄131I活度分数,对20例经甲状腺切除术后的DTC患者日尿排泄131I累积活度进行检测,以验证该模型计算结果.结果 采用优化模型估算DTC患者服药后第1日尿排泄131I活度分数为58.2%,服药后初始5 d总尿排泄131I活度分数为79.3%;用γ计数仪实际检测DTC患者服药后第1日尿排泄131I活度分数均值为57.9%,服药后初始5 d总尿排泄131I活度分数均值为79.9%.结论 优化的DTC患者隔室模型计算日尿排泄131I活度分数简单方便,估算的日尿排泄131I活度分数值与实际检测结果吻合较好.该模型可用于估算经甲状腺切除术后的甲状腙癌患者日尿排泄131I活度分数,有助于放射性废物管理以及患者周围人员防护.Objective To study the methodology for calculating daily urine intake excretion fraction of 131I in differentiated thyroid carcinoma（ DTC ） patients underwent thyroidectomy. Methods Simplified the current 131I compartment model with a normal thyroid. A new model was developed for calculating 131I activity excreted by urine of DTC patients. To verifiy the new method, 20 DTC patients treated with 131I therapy after thyroidectomy were investigated by measuring their daily urinary radioactivities of 131I during isolation period in this study. Results Daily urine intake excretion fractions were estimated to be 58.2% and 79.3% for the first day and 5 d respectively; the mean value for intake excretion fractions in the 20 DTC patients were 57.9% and 79.9% for the first day and 5 d respectively. Conclusions In good agreement with experimental results, the new method developed in this study was applicable to estimate the urine radioactivity intake excretion fractions of DTC patients underwent thyroidectomy. With the knowledge of daily urine intake excretion fractions, the isolation and urine storage time of DTC patients can be confirmed.

关 键 词：甲状腺肿瘤 碘放射性同位素 辐射监测 尿 放射性活度 

分 类 号：R736.1[医药卫生—肿瘤]