当归超微粉体和普通粉体的粉体学性质比较  

Comparative Study on Properties of Angelica in Ultrafine Powder and Common Powder

作　　者：陈绪龙[1] 赵国巍[1] 廖正根[1] 梁新丽[1] 王光发[1] 祝婧云[1] 招丽君[1] 蒋且英 

机构地区：[1]江西中医学院现代中药制剂教育部重点实验室,南昌330004 [2]江西中医学院成人教育学院,南昌330006

出　　处：《中国实验方剂学杂志》2010年第18期1-5,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家中医药管理局公益性行业科研专项(200807054);十一五重大新药创制项目(2009ZX09310-005);江西省对外科技合作项目(2008BB24800)

摘　　要：目的:比较当归超微粉体和普通粉体的粉体学性质,为超微粉粹应用于当归提供试验依据。方法:通过测定当归粉体的粒径及分布、吸湿性、粉体的形貌结构等粉体学特征和体外溶出行为,研究当归粉体的粒径对其粉体学特性、含量和体外溶出行为的影响。结果:随当归粉体粒度的减小,比表面积及孔容和吸湿性增加,流动性变弱,4种粉体中阿魏酸含量大小顺序为普通粉>微粉Ⅰ>微粉Ⅱ>微粉Ⅲ,但是随着粉碎程度的加强,微粉Ⅱ中的阿魏酸溶出速率、累积溶出率和溶出总量均高于其它粒径级别的当归粉体。结论:适度的微粉化能促进当归有效成分的溶出。Objective：To compare the powder properties between common powder and micropowders of Angelica to provide experimental evidence for the superfine grinding application. Method：Morphology structure, hygroscopic property, liquidity, surface area and porosity of Angelica powders were investigated; the contents and the dissolution of ferulic acid of Angelica powders were determined by HPLC. Result： With the decreasing of particle size of powders, the surface area, pore volume and moisture increased, and the liquidity decreased; the contents of ferulic acid from four Angelica powders were in the order of： common powder 〉 uhrafine powder I 〉 ultrafine powder II 〉 ultrafine powder III; but with the crushing level increased, dissolution rate and the total dissolution of the ultrafine powder II was higher than levels of particle size in other angelica powder. Conclusion ： An appropriate degree of micronization is helpful for the dissolution of the active components in Angelica.

关 键 词：当归 超微粉碎 粉体学性质 体外溶出行为 

分 类 号：R283.6[医药卫生—中药学]