Recurrent Patterns and Factors Involved in Node-negative Advanced Gastric Cancer  被引量:1

Recurrent Patterns and Factors Involved in Node-negative Advanced Gastric Cancer

在线阅读下载全文

作  者:En-Yi Liu Mei-Zuo Zhong Cai-Gang Liu Jin Huang Wei Liu Shan Zeng Bin Li Jing-Chen Lu Jian-Huang Li Hai-Rong Jiang 

机构地区:[1]Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China [2]Department of Surgical Oncology, First Hospital, China Medial University, Shenyang 110001, China

出  处:《Chinese Journal of Cancer Research》2010年第4期285-290,共6页中国癌症研究(英文版)

摘  要:Objective: To investigate the recurrent patterns and factors involved in node-negative advanced gastric cancer after curative resection. Patients and Methods: Clinicopathological characteristics and prognostic outcomes of 310 patients who had lymph node-negative advanced gastric adenocarcinoma and received curative resection between 2002 and 2006 were retrospectively evaluated. Results: Among the 300 patients, 15 (5.0%) had locoregional recurrence, 5 (1.7%) had lymph node recurrence, 27 (9.0%) had peritoneal seeding recurrence, and 21 (7.0%) had hematogenous metastasis. Using multivariate analysis, we found that the maximum tumor diameter (P=0.014), histological type (P=0.001) and Borrmann type (P=0.033) were independent factors predicting the locoregional recurrence. Lymph node recurrence was significantly affected by lymph node dissection (P=0.029) and lymphovascular invasion (P=0.004). Clinicopathological factors predicting the peritoneal seeding recurrence were the depth of invasion (P=0.001) and Borrmann type (P=0.002). In addition, lymphovascular invasion (P=0.013) and histological type (P=0.001) were significantly associated with hematogenous metastasis. Conclusion: Node-negative advanced gastric cancer has a high amount of peritoneal seeding and hematogenous metastasis.Objective: To investigate the recurrent patterns and factors involved in node-negative advanced gastric cancer after curative resection. Patients and Methods: Clinicopathological characteristics and prognostic outcomes of 310 patients who had lymph node-negative advanced gastric adenocarcinoma and received curative resection between 2002 and 2006 were retrospectively evaluated. Results: Among the 300 patients, 15 (5.0%) had locoregional recurrence, 5 (1.7%) had lymph node recurrence, 27 (9.0%) had peritoneal seeding recurrence, and 21 (7.0%) had hematogenous metastasis. Using multivariate analysis, we found that the maximum tumor diameter (P=0.014), histological type (P=0.001) and Borrmann type (P=0.033) were independent factors predicting the locoregional recurrence. Lymph node recurrence was significantly affected by lymph node dissection (P=0.029) and lymphovascular invasion (P=0.004). Clinicopathological factors predicting the peritoneal seeding recurrence were the depth of invasion (P=0.001) and Borrmann type (P=0.002). In addition, lymphovascular invasion (P=0.013) and histological type (P=0.001) were significantly associated with hematogenous metastasis. Conclusion: Node-negative advanced gastric cancer has a high amount of peritoneal seeding and hematogenous metastasis.

关 键 词:Gastric cancer RECURRENCE Lymph node PROGNOSIS 

分 类 号:R735.2[医药卫生—肿瘤]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象